COL16A1
| Collagen type XVI, alpha 1 | ||
|---|---|---|
| other names |
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| Properties of human protein | ||
| Mass / length primary structure | 1,604 amino acids , 157,751 Da | |
| Identifier | ||
| Gene names | COL16A1; FP1572; 447AA | |
| External IDs | ||
| Occurrence | ||
| Parent taxon | Euteleostomi | |
| Orthologue | ||
| human | House mouse | |
| Entrez | 1307 | 107581 |
| Ensemble | ENSG00000084636 | ENSMUSG00000040690 |
| UniProt | Q07092 | Q8BLX7 |
| Refseq (mRNA) | NM_001856 | NM_028266 |
| Refseq (protein) | NP_001847.3 | NP_082542.3 |
| Gene locus | Chr 1: 31.65 - 31.7 Mb | Chr 4: 130.05 - 130.1 Mb |
| PubMed search | 1307 |
107581
|
Collagen type XVI, alpha 1 is a fibrillenassoziiertes collagen that the gene COL16A1 is encoded. It forms homotrimers , which in turn form type XVI collagen fibrils .
properties
Type XVI, alpha 1 collagen is mainly found in fibroblasts and keratinocytes ; also in the smooth muscles and in the amnion . It is involved in cell adhesion and induces integrin- mediated cellular responses such as proliferation . Collagen XVI may act as a substrate for the adhesion and invasion of tumor cells in connective tissue . Thus it plays an important role in the interaction of the connective tissue with the extracellular matrix .
In addition, collagen promotes XVI the life of intestinal sub epithelial myofibroblasts (engl. Intestinal subepithelial myofibroblasts , ISEMF) in the intestinal wall by the focal adhesions interaction cell-matrix stabilized by, but α by the recruitment of the integrin 1 β 1 in the Tips of the focal contacts.
The NC11 domain of collagen XVI serves as a potential biomarker for squamous cell carcinoma and triggers vascular mimicry by upregulating the endothelial receptors VEGFR1 , VEGFR2 and uPAR .
Web links
Individual evidence
- ↑ James C. McConnell, Oliver V. O'Connell, Keith Brennan, Lisa Weiping, Miles Howe, Leena Joseph, David Knight, Ronan O'Cualain, Yit Lim, Angela Leek, Rachael Waddington, Jane Rogan, Susan M. Astley, Ashu Gandhi, Cliona C. Kirwan, Michael J. Sherratt, Charles H. Streuli: Collagen XVI in health and disease . In: Matrix Biol . 32, No. 2, March 11, 2013, pp. 64-73. doi : 10.1016 / j.matbio.2012.11.001 . PMID 23149016 .
- ↑ S. Ratzinger, JA Eble, A. Pasoldt, A. Opolka, G. Rogler, J. Girfka, S. Grässel: Collagen XVI induces formation of focal contacts on intestinal myofibroblasts isolated from the normal and inflamed intestinal tract . In: Matrix Biol . 29, No. 3, April 2010, pp. 177-193. doi : 10.1016 / j.matbio.2009.11.004 . PMID 19931388 .
- ↑ KB Bedal, S. Grässel, G. Spanier, TE Reichert, RJ Bauer: The NC11 domain of human collagen XVI induces vasculogenic mimicry in oral squamous cell carcinoma cells . In: Carcinogenesis . 36, No. 11, November 2015, pp. 1429–1439. doi : 10.1093 / carcin / bgv141 . PMID 26424749 .