Carbamoyl phosphate

Structural formula
General
Surname	Carbamoyl phosphate
Molecular formula	CH 4 NO 5 P
External identifiers / databases
CAS number 590-55-6 EC number 804-242-5 ECHA InfoCard 100.230.975 PubChem 278 Wikidata Q424409
properties
Molar mass	141.02 g mol −1
safety instructions
GHS labeling of hazardous substances danger H and P phrases H: 301-315-319-335 P: ?
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Carbamoyl phosphate is the mixed anhydride of the phosphate ion and carbamic acid and plays a major role in various metabolic processes. It is an intermediate stage in the breakdown of nitrogen compounds in the urea cycle and serves as the starting substance for the biosynthesis of pyrimidines .

In the urea cycle , it is represented in the mitochondria in a complex reaction of hydrogen carbonates , ammonia and phosphates and ATP as an energy supplier. The enzyme carbamoyl phosphate synthetase I serves as a biocatalyst in the synthesis .

${\displaystyle \mathrm {HCO_{3}^{-}+ATP\longrightarrow } }$ ${\displaystyle \mathrm {ADP+HO{-}COO{-}PO_{3}^{2-}} }$

${\displaystyle \mathrm {HO{-}COO{-}PO_{3}^{2-}+NH_{3}+OH^{-}\longrightarrow } }$ ${\displaystyle \mathrm {HPO_{4}^{2-}+H_{2}N{-}COO^{-}+H_{2}O} }$

${\displaystyle \mathrm {H_{2}N{-}COO^{-}+ATP\longrightarrow } }$ ${\displaystyle \mathrm {ADP+H_{2}N{-}COO{-}PO_{3}^{2-}} }$

In the synthesis of pyrimidines, the synthesis takes place with the help of carbamoyl phosphate synthetase II in the cytosol , whereby glutamine plays a role as the starting material.

Individual evidence

1. ↑ There is not yet a harmonized classification for this substance . A label of [No public or meaningful name is available] in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on December 28, 2019, is derived from a self-classification by the distributor .
2. ^ Peter Karlson, Detlef Doenecke: Karlsons Biochemie und Pathobiochemie . Georg Thieme Verlag, 2005, ISBN 978-3-13-357815-8 , p. 99 ( limited preview in Google Book search).
3. ↑ ^{a b} H. Robert Horton and Laurence A. Moran: Biochemistry . Pearson Deutschland GmbH, 2008, ISBN 978-3-8273-7312-0 , p. 751 ( limited preview in Google Book search).

Web links

• Entry for carbamoyl phosphate in the Human Metabolome Database (HMDB) , accessed September 24, 2013.

Wikibooks: Urea Cycle  - Learning and Teaching Materials

Wikibooks: Pyrimidine Metabolism  - Learning and Teaching Materials