Christoph Klein (doctor)

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Christoph Klein (born August 18, 1964 in Kirchen (Sieg) ) is a German pediatric hematologist and oncologist . Since 2011 he has been the Medical Director of the Children's Clinic and Children's Polyclinic at Dr. von Hauner's Children's Hospital at the Ludwig Maximilians University in Munich .

Life

After graduating from high school in Ehingen in 1983, Christoph Klein studied philosophy and medicine in Ulm, Harvard and Munich on a scholarship from the Cusanuswerk . In 1990 he completed his medical degree and obtained his doctorate in 1991. med. In 1993 he completed his philosophy studies with a Magister Artium . In 2000 he obtained his doctorate in sciences from the University of Pierre and Marie Curie in Paris.

He completed his pediatric training at the Dr. von Hauner's Children's Hospital at the Ludwig Maximilians University in Munich and at the Children's Clinic at the Albert Ludwig University in Freiburg . At the Hôpital Necker , Paris , he received special training in pediatric immunology. He completed a clinical fellowship in pediatric hematology / oncology at the Boston Children's Hospital of Harvard Medical School and subsequently taught there as a lecturer. In 2000, Klein was offered a professorship at the Friedrich-Alexander University Erlangen-Nuremberg and the Hannover Medical School . From 2008 to the beginning of 2011 he was Medical Director of the Clinic for Pediatric Hematology and Oncology at the Hannover Medical School. On March 1, 2011, he moved to the Ludwig Maximilians University in Munich as director of the University Children's Clinic.

science

Klein's scientific interests focus on the molecular pathophysiology of primary immunodeficiency diseases , the biology of stem cells and hematopoiesis , gene therapy and tumor immunology . Christoph Klein's working group discovered several congenital diseases of the blood and immune system and clarified their genetic and pathophysiological causes (including HAX1, LAMTOR2, G6PC3, IL10RA and IL10RB, VPS45, CSF3R, STK4, IL21R, JAGN1, MYSM1, SMARCD2, CARMIL2, , CD137). In addition, the team laid the foundations for new genetic and cellular therapy methods for children with rare diseases of the immune system (e.g. the genetic correction of blood stem cells in Wiskott-Aldrich syndrome , therapy of early childhood intestinal inflammation using allogeneic blood stem cells).

Christoph Klein founded the interdisciplinary German study group to research lymphoproliferative diseases after organ transplantation. He is the founding spokesman of the German research associations on rare diseases , a member of many specialist societies and coordinator of various national and international research associations. Since 2012 he has headed the Munich Center for Rare Diseases.

In 2018 he established the international Ph.D. course "Genomic and Molecular Medicine - Personalized Approaches to Childhood Health" at the Munich Medical Research School of the Ludwig Maximilians University .

In 2010, Christoph Klein was the first pediatrician to be awarded the Gottfried Wilhelm Leibniz Prize by the German Research Foundation for his scientific achievements .

Social Commitment

Christoph Klein has been campaigning for the best possible medical care for seriously ill children for many years. In 2009, together with the lawyer Andreas Staudacher, he founded the Care-for-Rare Foundation , a non-profit foundation for children with rare diseases . The foundation's vision is that children no longer have to die of their rare illness and receive the appropriate medical help - regardless of their ethnic origin and the financial possibilities of their family.

In addition, Klein is committed to improving the psychosocial care of seriously ill children in Germany and called on Dr. von Haunersche Children's Hospital in Munich launched the first German Child Life Specialists program.

As an advocate for sick children, Christoph Klein regularly speaks out in public and advocates greater respect for sick children. Together with other representatives of German university paediatrics, he organized the 1st German Children's Health Summit in April 2019 in order to strengthen the academic discourse on the importance of the UN Convention on the Rights of the Child for the German health care system.

As a co-founder of an initiative to increase civic engagement (pro.movere), he also coordinates the annual awarding of the Bavarian Stifterpreis under the patronage of the Duke of Bavaria .

Awards

  • 2016: Khwarizmi International Award, Islamic Republic of Iran
  • 2016: Prize for the Care-for-Rare Foundation as Science Foundation of the Year, German University Foundation
  • 2015: Cusanus Prize, Cusanuswerk Foundation for the Promotion of Talented Students
  • 2014: Member of the American Society for Clinical Investigation
  • 2013: Hector Science Award and member, Hector Fellow Academy
  • 2011: William Dameshek Prize, American Society of Hematology
  • 2011: Paul Martini Prize
  • 2011: Eva Luise Köhler Research Award
  • 2011: European Research Council Advanced Grant EXPLORE
  • 2010: Gottfried Wilhelm Leibniz Prize
  • 2007: Adalbert Czerny Prize
  • 2007: Rudolf Schoen Prize
  • 2007: GlaxoSmithKline Prize
  • 2006: Kind Philipp Prize, Society for Pediatric Oncology and Hematology
  • 2006: Yamagiwa-Yoshida Memorial Award (UICC), Japan
  • 1998: Scholar Award, American Society of Hematology

Others

The Süddeutsche Zeitung Magazin published an article in 2016 in which Professor Klein was presumed to have acted immorally on the back of sick children. The article reports on a gene therapy study for the treatment of the rare Wiskott-Aldrich syndrome , a life-threatening disorder of the blood and immune system. From 2006 to 2009, after years of intensive research and ethical reflection with experts in bioethics, Klein and his team initiated one of the world's first stem cell therapy studies to give sick children hope of healing who would have had little chance of a healthy life without experimental therapy . The innovative stem cell therapy initially led to partial or complete healing in nine out of ten patients. They could lead healthy lives with a good quality of life. Several years later, however, the treated patients developed leukemia as a result of gene therapy , which in turn required intensive treatment. The statistical long-term survival rate of 70% was not higher than the value that would have been expected from a conventional transplantation of blood stem cells , which is full of complications .

However, SZ-Magazin made the claim that some patients could have been cured with conventional stem cell therapy, but they were included in the study and treated with a high-risk gene therapy method. The increased leukemia risk of the gene ferries used in the study was known before the start of the study. The article also assumed that the children's parents had not been fully informed and that the ethics committee had not assessed the study in accordance with the rules.

Christoph Klein took legal action against these allegations and obtained two preliminary injunctions against the SZ-Magazin and the reporter Johannes Boie (District Court Hamburg Az. 324 O 268/16, Az. 324 O 536/16, Az. 324 O 268/16) . The Hamburg Regional Court announced on September 8, 2017 that the suspicious activity reports by SZ-Magazin were unlawful from the start and had seriously interfered with the general personality rights of the doctor (Hamburg Regional Court Az. 324 O 795/16). The Magazin Verlagsgesellschaft Süddeutsche Zeitung mbH was sentenced to corrective reporting in the sense of an addendum.

Due to the inaccurate reporting by SZ-Magazin on many points, the medical faculty of the Ludwig Maximilians University in Munich commissioned an independent review of the medical, legal and ethical aspects of the study. A commission of renowned professors comes to the conclusion on the basis of its own inspection and assessment as well as on the basis of external expert reports: "There is no evidence of scientific, medical, legal or ethical misconduct by Prof. Dr. med. Dr. sci. nat. Christoph Klein on the implementation of the clinical phase I / II study, feasibility, safety and effectiveness of the transplantation of retrivirally transduced hematopoietic stem cell therapy of the Wiskott-Aldrich syndrome. "

The parents of the treated patients stand behind Professor Klein and expressed their incomprehension in view of the reporting. Doctors and scientists from Germany, Austria, the USA, Canada and Japan also criticized the "character assassination campaign" of the SZ magazine in an open letter.

Web links

Individual evidence

  1. ↑ Children's clinic and children's outpatient clinic in the Dr. von Haunersche Children's Hospital, management. Retrieved December 5, 2019 .
  2. ↑ a b Curriculum Vitae Prof. Christoph Klein. DFG - Gottfried Wilhelm Leibniz Prize 2010, accessed on December 5, 2019 .
  3. ↑ Management & Krankenhaus - magazine for decision-makers in the healthcare sector. Retrieved August 12, 2018 .
  4. ↑ a b Klein Lab - Publications. Retrieved May 9, 2018 .
  5. ^ The Pediatric PTLD Registry. Retrieved May 9, 2018 .
  6. ↑ Network Research for Rare - research for rare diseases. Retrieved April 4, 2018 .
  7. ↑ International Union of Immunological Societies. Retrieved April 4, 2019 .
  8. ↑ Munich Center for Rare Diseases. Retrieved April 4, 2018 .
  9. ↑ PhD program in Genomic and Molecular Medicine - Personalized Approaches to Childhood Health. Munich Medical Research School, LMU, accessed December 5, 2019 .
  10. ↑ a b Gottfried Wilhelm Leibniz Prize for Prof. Christoph Klein. German Research Foundation (DFG), accessed on April 4, 2018 .
  11. ^ Care-for-Rare Foundation - Foundation for children with rare diseases. Retrieved November 8, 2018 .
  12. ↑ The Child Life Specialist Program at Dr. von Hauner's Children's Hospital. Retrieved December 16, 2019 .
  13. ↑ Sick children are the losers. Article by Prof. Christoph Klein and Prof. Charlotte Niemeyer in the Frankfurter Allgemeine Zeitung on February 14, 2018, accessed on December 16, 2019 .
  14. ↑ Sick children are neglected everywhere. Interview Prof. Christoph Klein in Baby & Family from September 2019, accessed on December 5, 2019 .
  15. ↑ A clinic for rare diseases. Spiegel TV report from May 2014, accessed on December 5, 2019 .
  16. ↑ Help for the orphans of medicine. Article in Münchner Merkur from April 15, 2019, accessed on December 5, 2019 .
  17. ↑ 1st German Children's Health Summit. Website of the initiative “Sick Children Have Rights”, accessed on December 16, 2019 .
  18. ↑ Strengthen children's rights in clinics too. Interview with Prof. Christoph Klein in the newspaper Würzburg from February 2019, accessed on December 16, 2019 .
  19. ↑ Children's clinics complain about pressure. Report in ZDF heute journal on April 29, 2019 , accessed on December 16, 2019 .
  20. ↑ More rights for children in clinics. Article in the Ärzte Zeitung of April 30, 2019 , accessed on December 16, 2019 .
  21. ↑ pro.movere. Retrieved December 5, 2019 .
  22. ↑ Iranian Science Prize for Prof. Klein. Ludwig Maximilians University of Munich, accessed on February 15, 2018 .
  23. ↑ Science Foundation of the Year. German University Association, accessed on February 15, 2018 .
  24. ↑ Awarding of the Cusanus Prize. Retrieved February 15, 2018 .
  25. ^ ASCI - The American Society for Clinical Investigation. Retrieved February 15, 2018 .
  26. ↑ Foundation wants to give impulses for innovations. Retrieved February 15, 2018 .
  27. ^ American Society of Hematology Recognizes Christoph Klein with William Dameshek Prize. Retrieved March 17, 2018 .
  28. ↑ Award for gene therapy that helps children with rare diseases. Retrieved March 17, 2018 .
  29. ^ Eva Luise Köhler Research Award for the gene therapy of rare diseases. Retrieved March 17, 2018 .
  30. ^ European Research Council. Retrieved March 17, 2018 .
  31. ^ German Society for Child and Adolescent Medicine. Retrieved April 4, 2018 .
  32. ↑ Rudolf Schoen Prize 2007 for the discovery of the genetic cause of Kostmann syndrome. Retrieved April 4, 2018 .
  33. ^ GlaxoSmithKline Foundation. Retrieved April 4, 2018 .
  34. ↑ Kind-Philipp-Preis goes to Christoph Klein. Retrieved April 4, 2018 .
  35. ↑ Annual Report UICC 2006. Accessed April 4, 2018 .
  36. ↑ ASH Scholar Awards Recipients. Retrieved April 4, 2018 .
  37. ^ German Research Foundation - Funded Projects. Retrieved November 9, 2018 .
  38. ↑ Ethical analysis of somatic gene therapy for Wiskott-Aldrich syndrome. Retrieved November 9, 2018 .
  39. ^ Stem-cell gene therapy for the Wiskott-Aldrich syndrome. Retrieved November 9, 2018 .
  40. ^ Gene therapy for Wiskott-Aldrich syndrome - long-term efficacy and genotoxicity. Retrieved November 9, 2018 .
  41. ↑ Reporting by the SZ magazine illegal. Retrieved November 9, 2018 .
  42. ↑ Hamburg District Court confirms preliminary injunction. Retrieved November 9, 2018 .
  43. ^ Final report on the gene therapy study in Wiskott-Aldrich syndrome. Retrieved November 9, 2018 .
  44. ↑ Statement from patient families. Retrieved November 9, 2018 .
  45. ↑ International scientists denounce "targeted character assassination campaign". Retrieved November 9, 2018 .
  46. ↑ Open letter from international scientists - support for Christoph Klein is growing. Retrieved November 9, 2018 .
personal data
SURNAME Klein, Christoph
BRIEF DESCRIPTION German pediatric oncologist
DATE OF BIRTH August 18, 1964
PLACE OF BIRTH Churches (victory)