Cilofungin

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Structural formula
Structure of cilofungin
General
Non-proprietary name Cilofungin
other names

1 - ((4 R , 5 R ) -4,5-dihydroxy- N 2- (4- (octyloxy) benzoyl) -l-ornithine) echinocandin B ( IUPAC )

Molecular formula C 49 H 71 N 7 O 17
External identifiers / databases
CAS number 79404-91-4
PubChem 6918120
ChemSpider 5293334
Wikidata Q908879
Drug information
Drug class

Antifungal agent

properties
Molar mass 1030.14 g · mol -1
safety instructions
GHS hazard labeling
no classification available
Toxicological data

125 mg kg −1 ( LD 50 ,  rat ,  iv )

As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Cilofungin is an antifungal from the echinocandins group . It inhibits the cell wall biosynthesis in some Candida albicans species. Phase II development was discontinued due to the toxicity of the carrier substance (manufacturer: Eli Lilly & Co. ).

pharmacology

Cilofungin inhibits glucan synthase , which is responsible for the formation of beta-1-3- glucan , a major component of most pathogenic fungi . This makes the cell wall unstable. In addition, the mycelium growth is inhibited and the uptake of N -acetylglucosamine in the mycelium is blocked.

literature

Analytics:

  • Wood, Miller, Wright, Mc Carthy, Traft, Pomponi, Selitremihoff: Journal of Antibiotics 51, pp. 665-675 (1998).

Synthesis:

  • Debono, Abbott, Fukuda, Barnhart, Eillard, Molloy, Michel, Turner, Butler, Hunt: Journal of Antibiotics 42 (3), pp. 389-397 (1998).

Pharmacology:

Individual evidence

  1. ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
  2. ↑ Entry on cilofungin in the ChemIDplus database of the United States National Library of Medicine (NLM) .