Clostridium kluyveri
| Clostridium kluyveri | ||||||||||||
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| Clostridium kluyveri | ||||||||||||
| Barker 1937 |
Clostridium kluyveri is an anaerobic , gram-positive , rod-shaped bacterium and belongs to the endospore-forming family of the Clostridiaceae . A distinguishing feature is its ability toconvert ethanol into caproic acid. It grows on ethanol and acetate and produces, besides caproates, butyrates and hydrogen .
Clostridium kluyeri does not cause disease, so it is non-pathogenic .
Research history
This bacterium was first isolated in 1937 by the American microbiologist H. A. Barker from the mud of a canal in Delft , the Netherlands .
At Berkeley University in California , this bacterium was then the model for studying fatty acid synthesis and degradation in the 1950s, which was used to gain knowledge about metabolic processes in the liver.
A research team made up of microbiologists from the Philipps University of Marburg , the Max Planck Institute for Terrestrial Microbiology Marburg and the Georg August University of Göttingen decoded the genome of Clostridium kluyveri . The sequence information and accompanying investigations made it possible to explain the metabolic process that enables this bacterium to produce hydrogen from alcohol in order to meet its energy requirements. The research results were published on January 15, 2008 in the online edition of the PNAS (Proceedings of the National Academy of Sciences of the United States of America).
According to the Marburg publication, four gene groups that code for so-called polyketides that could possibly have an antibiotic effect are awaiting further research .
Evidence, sources
- ↑ http://www.gopubmed.org/GoMeshPubMed/gomeshpubmed/?tool=HotTopicDirect&termAlt=mesh%2347010 .
- ↑ a b Seedorf, H. et al. (2008): The genome of Clostridium kluyveri, a strict anaerobe with unique metabolic features . In: Proc Natl Acad Sci USA. 105 (6); 2128-2133; PMID 18218779 ; PDF (free full text access).
- ↑ a b c respect the metabolic energy of Clostridium kluyeri explored (University of Marburg, January 15, 2008).