Clotiapine

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Structural formula
Structural formula of clothiapin
General
Surname Clotiapine
other names
  • 2-chloro-11- (4-methyl-1-piperazinyl) dibenzo [ b , f ] [1,4] thiazepine
  • Clothiapine
  • HF 2159
Molecular formula C 18 H 18 ClN 3 S
Brief description

white solid

External identifiers / databases
CAS number 2058-52-8
EC number 218-162-8
ECHA InfoCard 100.016.512
PubChem 16351
Wikidata Q3661095
Drug information
ATC code

N05 AH06

properties
Molar mass 343.87 g mol −1
Physical state

firmly

density

1.24 g cm −3

Melting point

118-120 ° C

solubility

slightly soluble in chloroform , DMSO and methanol

safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances
06 - Toxic or very toxic

danger

H and P phrases H: 301
P: 264-301-310
Toxicological data

280 mg kg −1 ( LD 50 ,  rat ,  oral )

As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Clotiapine (trade name: Entumin ) is a chemical compound that belongs to the dibenzothiazepines . It is used as a neuroleptic . It has been approved in Switzerland since 1967 for the treatment of schizophrenia and other mental illnesses.

Effects

Clotiapine is a strongly sedating neuroleptic with high side effects. It can cause pancreatitis .

See also

Individual evidence

  1. ↑ a b c d e Entry on Clotiapine at Toronto Research Chemicals , accessed on July 30, 2017 ( PDF ).
  2. ^ Carl L. Yaws: Thermophysical Properties of Chemicals and Hydrocarbons . William Andrew, 2014, ISBN 978-0-323-29060-9 , p. 335.
  3. ↑ Richard J. Lewis: Hazardous Chemicals Desk Reference . John Wiley & Sons, 2008, ISBN 0-470-33445-2 , p. 1472.
  4. ↑ Pharmawiki: Clotiapine.
  5. ↑ technical information Entumin (Medius AG), as of April, 2013.
  6. ^ Margot Schmitz, Rainer Dorow: 1 × 1 of the psychotropic drugs basics, standard therapies and new concepts . Springer-Verlag, 2013, ISBN 978-3-662-05542-7 , p. 157.
  7. ^ JK Aronson: Meyler's Side Effects of Psychiatric Drugs . Elsevier, 2009, ISBN 978-0-444-53266-4 , p. 261.