Diethylenetriaminepentaacetic acid

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Structural formula
Structure of diethylenetriaminepentaacetic acid
General
Surname Diethylenetriaminepentaacetic acid
other names
  • Diethylenetriaminepentaacetic acid
  • Pentetic acid
  • N , N -Bis (2- (bis (carboxymethyl) amino) ethyl) glycine
  • 3-aza-3- (carboxymethyl) pentamethylene dinitrilotetraacetic acid
Molecular formula C 14 H 23 N 3 O 10
Brief description

white solid

External identifiers / databases
CAS number 67-43-6
EC number 200-652-8
ECHA InfoCard 100,000,593
PubChem 3053
ChemSpider 2945
DrugBank DB14007
Wikidata Q416487
properties
Molar mass 393.35 g mol −1
Physical state

firmly

density

1.56 g cm −3

Melting point

220 ° C

solubility

soluble in water (4.8 g l −1 at 25 ° C)

safety instructions
GHS labeling of hazardous substances
07 - Warning 08 - Dangerous to health

Caution

H and P phrases H: 319-332-361d
P: 281-305 + 351 + 338
Toxicological data

587 mg kg −1 ( LD 50 ,  rat ,  ip )

As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Diethylenetriaminepentaacetic acid ( DTPA ) is a five-protonic acid and is chemically related to EDTA . It is used as a chelating complexing agent. Their salts are called "pentetates".

The excellent complex formation properties, especially in the case of metal cations with a large ionic radius, make DTPA ideal for use in medicine and agriculture in fertilizers. For example, it is used in chelation therapy to detoxify after accidents with heavy metals and to complex gadolinium as a contrast agent ( gadopentetate dimeglumine ) in MRI examinations.

Extraction and presentation

DTPA is obtained by reacting diethylenetriamine with formaldehyde and sodium cyanide in the presence of sodium hydroxide.

Individual evidence

  1. ↑ a b Datasheet Diethylenetriaminepentaacetic acid from Acros, accessed on December 6, 2016.
  2. ↑ Data sheet Diethylenetriaminepentaacetic acid from AlfaAesar, accessed on February 11, 2010 ( PDF )(JavaScript required) .
  3. ↑ a b Entry on pentetic acid in the ChemIDplus database of the United States National Library of Medicine (NLM), accessed on December 6, 2016.
  4. ↑ a b Datasheet Diethylenetriaminepentaacetic acid from Sigma-Aldrich , accessed on December 6, 2016 ( PDF ).