David M. Sabatini
David Marcelo Sabatini (born January 27, 1968 in Westchester County , New York ) is a molecular biologist known for studying the regulation of growth processes in mammalian cells, especially the discovery and investigation of mTOR . He is Professor of Biology at the Massachusetts Institute of Technology (MIT) and the Whitehead Institute there.
Sabatini studied medicine at Johns Hopkins University with an MD degree and Ph. D. with Solomon Snyder in 1997. In his group, he specifically examined the growth regulation in mammalian cells via the cells developed by him and Snyder - as well as by Robert Abraham and Stuart L. Schreiber at Harvard - discovered mTOR (mammalian target of rapamycin ) mechanism, about which he already wrote his dissertation. Various TOR genes as a starting point for rapamycin in yeast cells were previously discovered in the early 1990s by researchers at Sandoz in Basel (which they named after a city gate to Basel); mTOR is specific for mammalian cells. It is named after the antibiotic rapamycin, which attacks the mTOR complex. Sabatini and co-workers explained the role of a number of proteins that play a role in regulation via the mTOR complex. mTOR plays a central role in growth regulation and drugs such as rapamycin are not only important as antibiotics, but also in cancer, cardiovascular diseases, transplants, kidney diseases, aging, Alzheimer's, diabetes and the like. a.
His laboratory is also developing the technology of cell-based microarrays, which enable the disruption of the function of thousands of genes in a cell to be examined in parallel. He is also involved in building an RNA interference library for human and mouse cells.
In 2014 Sabatini received the NAS Award in Molecular Biology and in 2016 he was elected to the National Academy of Sciences . Since 2016 Thomson Reuters has counted him among the favorites for a Nobel Prize ( Thomson Reuters Citation Laureates ) due to the number of his citations . For 2017, Sabatini received the Dickson Prize in Medicine and the Lurie Prize in Biomedical Sciences . In 2019 he was awarded the Louisa Gross Horwitz Prize and the BBVA Foundation Frontiers of Knowledge Award . For 2020 he was awarded the Sjöberg Prize .
He should not be confused with the Argentine-US cell biologist David D. Sabatini .
Individual evidence
- ↑ Web of Science Predicts 2016 Nobel Prize Winners. (No longer available online.) In: ipscience.thomsonreuters.com. September 21, 2016, archived from the original on September 21, 2016 ; accessed on September 21, 2016 (English). Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice.
Web links
| personal data | |
|---|---|
| SURNAME | Sabatini, David M. |
| ALTERNATIVE NAMES | Sabatini, David Marcelo |
| BRIEF DESCRIPTION | American molecular biologist |
| DATE OF BIRTH | January 27, 1968 |
| PLACE OF BIRTH | Westchester (New York) |