Demecolcin

Structural formula
General
Non-proprietary name	Demecolcin
other names	( S ) -6,7-Dihydro-1,2,3,10-tetramethoxy-7- (methylamino) benzo [ a ] heptalen-9 (5 H ) -one ( IUPAC ) ; Colcemid; ( S ) - (-) - N -methyl- N -desacetylcolchicine; ( S ) - (-) - N -deacetyl- N -methylcolchicine;
Molecular formula	C 21 H 25 NO 5
Brief description	light yellow solid
External identifiers / databases
EC number	207-514-6
ECHA InfoCard	100.006.832
PubChem	220401
ChemSpider	191135
Wikidata	Q903666
Drug information
ATC code	L01 CC01
properties
Molar mass	371.43 g mol −1
Physical state	firmly
Melting point	186 ° C
solubility	poor in water (1.65 g l −1 at 20 ° C)
safety instructions
	Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances danger
H and P phrases	H: 300
	P: 264-301 + 310
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Demecolcin is a poisonous alkaloid of the autumn crocus ( Colchicum autumnale ).

Occurrence

The blossom of the autumn crocus contains 1.8% colchicine and demecolcine.

Along with the main alkaloid colchicine, it is the second most common alkaloid of the autumn crocus.

effect

Demecolcine, like colchicine, is a mitosis inhibitor that inhibits the formation of spindle fibers (for a more detailed description, see colchicine ). In contrast to colchicine, demecolcine is about forty times less toxic to humans.

Individual evidence

↑ ^a ^b ^c ^d ^e Entry on Colcemid in the GESTIS substance database of the IFA , accessed on February 10, 2017(JavaScript required) .

Web links

Article about colchicine ( Memento of May 9, 2007 in the Internet Archive ) in the Lexicon of Alkaloids

[GESTIS-1] Entry on Colcemid in the GESTIS substance database of the IFA , accessed on February 10, 2017(JavaScript required) .