Demoxepam

Structural formula
General
Surname	Demoxepam
Molecular formula	C 15 H 11 ClN 2 O 2
Brief description	light yellow odorless solid
External identifiers / databases
ECHA InfoCard	100.012.287
PubChem	13756
ChemSpider	10441314
Wikidata	Q5256385
properties
Molar mass	286.71 g mol −1
Physical state	firmly
Melting point	235-240 ° C
safety instructions
GHS hazard labeling ; no classification available
GHS hazard labeling ; no classification available
Toxicological data	> 4000 mg kg −1 ( LD 50 , rat , oral ) ; > 290 mg kg −1 ( LD 50 , mouse , ip ) ;
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Demoxepam is a chemical compound from the group of benzodiazepines . It is also one of the primary metabolites of chlordiazepoxide .

Extraction and presentation

Demoxepam can be obtained by a multi-stage reaction starting from 4-chloroaniline ( 1 ) via 2-amino-5-chlorobenzophenone ( 3 ) and other intermediate products.

use

Demoxepam is a psychotropic agent from the class of benzodiazepines, which have a muscle-relaxing and amnestic effect. The plasma half-life in humans varies between 14 and 95 hours. This converts to a large number of different metabolites. It is used as an intermediate in the manufacture of oxazepam .

Individual evidence

↑ ^a ^b ^c ^d ^e lgcstandards: Demoxepam- CAS Number 963-39-3 , accessed on January 26, 2019
↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
↑ Data sheet Demoxepam solution, 1.0 mg / mL in acetonitrile, ampule of 1 mL, certified reference material from Sigma-Aldrich , accessed on January 26, 2019 ( PDF ).
↑ Google Patents: US3136815A - Amino substituted benzophenone oximes and derivatives thereof , accessed January 26, 2019.
^ Fv Bruchhausen, S. Ebel, AW Frahm, E. Hackenthal: Hager's handbook of pharmaceutical practice substances AD . Springer-Verlag, 2013, ISBN 978-3-642-57995-0 , pp. 1197 ( limited preview in Google Book Search).
^ Morton A. Schwartz, Edward Postma: Metabolites of Demoxepam, a Chlordiazepoxide Metabolite, in Man. In: Journal of Pharmaceutical Sciences. 61, 1972, p. 123, doi : 10.1002 / jps.2600610128 .
^ Maxwell Gordon: Psychopharmacological Agents . Elsevier, 2012, ISBN 978-0-323-15128-3 , pp. 190 ( limited preview in Google Book Search).

[lgcstandards.com-1] ↑ ^a ^b ^c ^d ^e lgcstandards: Demoxepam- CAS Number 963-39-3 , accessed on January 26, 2019

[NV-2] This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.

[Sigma-3] Data sheet Demoxepam solution, 1.0 mg / mL in acetonitrile, ampule of 1 mL, certified reference material from Sigma-Aldrich , accessed on January 26, 2019 ( PDF ).

[google.com-4] Google Patents: US3136815A - Amino substituted benzophenone oximes and derivatives thereof , accessed January 26, 2019.

[F.v._Bruchhausen,_S._Ebel,_A.W._Frahm,_E._Hackenthal-5] Fv Bruchhausen, S. Ebel, AW Frahm, E. Hackenthal: Hager's handbook of pharmaceutical practice substances AD . Springer-Verlag, 2013, ISBN 978-3-642-57995-0 , pp. 1197 ( limited preview in Google Book Search).

[DOI10.1002/jps.2600610128-6] Morton A. Schwartz, Edward Postma: Metabolites of Demoxepam, a Chlordiazepoxide Metabolite, in Man. In: Journal of Pharmaceutical Sciences. 61, 1972, p. 123, doi : 10.1002 / jps.2600610128 .

[Maxwell_Gordon-7] Maxwell Gordon: Psychopharmacological Agents . Elsevier, 2012, ISBN 978-0-323-15128-3 , pp. 190 ( limited preview in Google Book Search).