Chlordiazepoxide

Structural formula
General
Non-proprietary name	Chlordiazepoxide
Molecular formula	C 16 H 14 ClN 3 O
External identifiers / databases
CAS number 58-25-3 EC number 200-371-0 ECHA InfoCard 100,000,337 PubChem 2712 DrugBank DB00475 Wikidata Q178566
Drug information
ATC code	N05 BA02
Drug class	Benzodiazepine Anxiolytic
Mechanism of action	has a modulating effect on the binding site of the neurotransmitter GABA (γ-aminobutyric acid) at the GABA A receptor
properties
Molar mass	299.76  g · mol -1
Physical state	firmly
Melting point	230-232  ° C
safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed GHS labeling of hazardous substances Caution H and P phrases H: 302 P: no P-phrases
Toxicological data	200 mg kg −1 ( LD 50 ,  mouse ,  oral ) 392 mg kg −1 ( LD 50 ,  rat ,  oral )
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Chlordiazepoxide is a drug from the group of long-acting benzodiazepines . Its half-life is 36 to 200 hours, that of its main active metabolite, desmethylchlorodiazepoxide, is 24 to 96 hours.

Chlordiazepoxide is used for the symptomatic treatment of acute and chronic states of tension, excitement, and anxiety. The use of sleep disorders caused by tension, excitement and anxiety and requiring treatment is only indicated with restrictions, since the benzodiazepine effect also exists during the day due to its long half-life. Psychological and physical dependence can develop after only a short period of use .

Chlordiazepoxide was developed by Leo Sternbach and was the first benzodiazepine to be brought onto the market by Hoffmann-La Roche in 1960 .

In the Federal Republic of Germany, the drug chlordiazepoxide is subject to the legislation of the Narcotics Act ( BtMG ). It was included in Appendix III (marketable and prescription narcotics ). This does not apply to preparations which contain up to 25 mg of chlordiazepoxide per divided form without any other substance regulated by narcotics law; they can be prescribed without a prescription for narcotics.

Trade names

Monopreparations

Librium (D), Multum (D), Radepur (D)

Combination preparations

Limbatril (D), Librax (CH), Librocol (CH), Limbitrol (CH)

See also

• Benzodiazepine abuse

Individual evidence

1. ↑ ^{a b c} data sheet chlordiazepoxide ( memento of the original from December 14, 2013 in the Internet Archive ) Info: The archive link has been inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. (PDF; 69 kB) from LGC Standards, accessed on November 16, 2012. 
2. ↑ ^{a b} Datasheet Chlordiazepoxide-d ₅ from Sigma-Aldrich , accessed on October 31, 2016 ( PDF ).
3. ↑ Gossel, TA, JD Bricker. Principles of Clinical Toxicology. 3rd ed. New York, NY: Raven Press, Ltd., 1994, ISBN 0-7817-0125-2 , p. 314.
4. ^ American Medical Association. AMA Drug Evaluations Annual 1991. Chicago, IL: American Medical Association, 1991, ISBN 0-89970-401-8 , p. 216.
5. ^ Science Online Lexica: Entry on benzodiazepines in the Lexicon of Neurology.
6. ↑ Red List Online, as of August 2009.
7. ↑ AM comp. d. Switzerland, as of August 2009.
8. ↑ AGES-PharmMed, stand; August 2009.

This article is about a health issue. It is not used for self-diagnosis and does not replace a diagnosis by a doctor. Please note the information on health issues !