Dimercaptopropane sulfonic acid

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Structural formula
Structural formula of dimercaptopropane sulfonic acid
Structural formula without stereochemistry
General
Surname Dimercaptopropane sulfonic acid
other names
  • 2,3 dimercapto-1-propanesulfonic acid ( IUPAC )
  • ( RS ) -2,3-bis-sulfanylpropane-1-sulfonic acid
  • (±) -2,3-bis-sulfanylpropane-1-sulfonic acid
  • DMPS
  • Unithiol
Molecular formula C 3 H 8 O 3 S 3
Brief description

white to off-white solid (sodium salt, monohydrate)

External identifiers / databases
CAS number
PubChem 6321
Wikidata Q415659
Drug information
ATC code

V03 AB

Drug class

Antidote / complexing agent

Mechanism of action

Chelate complex formation

properties
Molar mass 188.29 g mol −1
Physical state

firmly

Melting point

229 ° C (sodium salt, monohydrate)

safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances
no GHS pictograms
H and P phrases H: no H-phrases
P: no P-phrases
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Dimercaptopropane sulfonic acid (DMPS) (trade name: Dimaval, manufacturer: Heyl) is an antidote (antidote) containing SH groups , which is used as a chelation therapy for the treatment of poisoning with heavy metals.

application

It is used for copper , lead , arsenic , mercury , gold , bismuth , antimony and chromium poisoning. In the case of poisoning with thallium , selenium , iron or cadmium , dimercaptopropane sulfonic acid is not useful. DMPS is used as a water-soluble sodium salt and can therefore also be administered intravenously slowly. As with any drug, the use of DMPS is associated with side effects. It should only be used under medical supervision.

Mode of action

The mode of action of DMPS is based on the formation of stable chelate complexes . This complex formation prevents the toxic metal ions from attaching to vital enzymes. In addition, the heavy metals bound as complexes are excreted more quickly.

origin

DMPS is the successor to Dimercaprol (BAL) - the latter is readily soluble in oil (lipophilic) and had to be injected into the muscle. The lipophilicity of dimercaprol also meant that more side effects occurred, as this substance can cross the blood-brain barrier and thus transport heavy metals into the brain.

Different application

DMPS is also used as an off-label use to test patients for heavy metal exposure, e.g. B. for cumulative deposits in the body from dental metals (e.g. amalgam and metals in crowns, bridges and implants). For this purpose, DMPS is injected once intravenously. The urine before and after administration is then examined for heavy metals. The administration of DMPS for diagnostic purposes is not a permitted use. This application is associated with the same risks as the application for detoxification, however, previously bound heavy metal can now be redistributed.

Individual evidence

  1. ↑ a b c d data sheet 2,3-Dimercapto-1-propanesulfonic acid sodium salt monohydrate, 95% from AlfaAesar, accessed on December 6, 2019 ( PDF )(JavaScript required) .
  2. ↑ a b c Wolfgang Bayer: Implementation, reference ranges and interpretation of the DMPS test A critical data analysis (pdf; 1.8 MB) www.himbeerrot-design.de. 2008. Retrieved February 22, 2011.
  3. ↑ Medical Laboratory Bremen: DMPS test .

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