Dimethylallyl pyrophosphate
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Surname | Dimethylallyl pyrophosphate | |||||||||||||||
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Molar mass | 246.09 g mol −1 (protonated) | |||||||||||||||
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As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
Dimethylallyl pyrophosphate ( dimethyl allyl PP or DMAPP for short , better: dimethyl allyl diphosphate DMADP ) is a biomolecule that can be found as a basic building block in terpene biosynthesis . From a chemical point of view, it is an ester of prenol (an alcohol with an additional C = C double bond ) and diphosphoric acid .
It is synthesized by the mevalonate biosynthetic pathway in the cytosol and is produced in the last step by the IPP isomerase from isopentenyl pyrophosphate (IPP). Feodor Lynen and Konrad Bloch received the Nobel Prize for Medicine in 1964 for their contribution to the discovery of the mevalonate biosynthetic pathway and the cholesterol metabolism .
In recent years, a second metabolic pathway to DMAPP and IPP has been discovered, the so-called MEP path ( methylerythritol phosphate path ). This metabolic pathway can be found in the plant plastids and in Plasmodium falciparum (the causative agent of malaria ). In addition to DMAPP, IPP is also created.
DMAPP and IPP are the starting substrates of around 30,000 terpenes known to date . In the human body, DMAPP and IPP are the basic substrates for the biosynthesis of hormones or cholesterol .
literature
- Albert L. Lehninger: Biochemistry , 2nd edition, Weinheim 1983, ISBN 3-527-25688-1 , p. 560.