Donald Hilvert

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Donald Michael Hilvert (* 1956 in Cincinnati , Ohio ) is an American chemist .

life and work

After completing his bachelor's degree at Brown University in 1978, Hilvert spent a year at ETH Zurich . He joined Ronald Breslow in 1983 at Columbia University with his work Enzyme Mechanisms & Models. Part I. Evidence for the General-Base Mechanism in Carboxypeptidase A-catalyzed Reactions. Part II. Thiazolium-Cyclodextrins as Holoenzyme Mimics of Thiamin-dependent Enzymes to Ph.D. PhD . As a post-doctoral student he worked with Emil Thomas Kaiser at Rockefeller University . He then moved to the Scripps Research Institute , first as an assistant professor (1986–1989), then as an adjunct professor (1989–1993) and finally as a professor (1994–1997). In 1995 he received the Janet and W. Keith Kellog II professorship. Since 1997 he has been Professor of Chemistry at the ETH Zurich.

Hilvert conducts research in the field of organic chemistry , especially proteins , enzymes and abzymes . By means of directed evolution he develops artificial enzymes with tailor-made catalytic properties. He takes an alternative approach by modifying natural enzymes: He modifies side chains or, for example, introduces selenocysteine into the molecule in order to create enzymes with new redox and hydrolytic properties. He is also studying the catalytic properties of monoclonal antibodies .

Awards

Individual evidence

  1. ↑ biographical data, publications and Academic pedigree of Donald M. Hilvert at academictree.org, accessed on February 12 2018th
  2. ^ Sean V. Taylor, Peter Kast, Donald Hilvert: Investigating and Engineering Enzymes by Genetic Selection . In: Angewandte Chemie International Edition . Volume 40, 2001, p. 3310.
  3. ↑ EB Peterson and D. Hilvert: Nonessential Active Site Residues Modulate Selenosubtilisin's Kinetic Mechanism . In: Biochemistry . Volume 34, 1995, pp. 6616-6620.
  4. ^ Donald Hilvert: Critical analysis of antibody catalysis . In: Annual Review of Biochemistry . Volume 69, 2000, pp. 751-793.
  5. ^ Fellows of the AAAS: Donald Hilvert. American Association for the Advancement of Science, accessed January 31, 2018 .
  6. ^ American Academy of Arts and Sciences : Newly Elected Fellows. In: amacad.org. Retrieved April 22, 2016 .

literature

  • Hubertus P. Bell: What's cooking in chemistry? How leading chemists succeed in the kitchen . Wiley-VCH, Weinheim 2003, pp. 93f., ISBN 3-527-30723-0 ( google books )

Web links

personal data
SURNAME Hilvert, Donald
ALTERNATIVE NAMES Hilvert, Donald Michael (full name)
BRIEF DESCRIPTION American chemist
DATE OF BIRTH 1956
PLACE OF BIRTH Cincinnati , Ohio