Enterocytozoon bieneusi
| Enterocytozoon bieneusi | ||||||||||||
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| Enterocytozoon bieneusi | ||||||||||||
| I. Desportes et al. |
Enterocytozoon bieneusi is a microsporidia species which, as an obligate intracellular parasite, can attack intestinal epithelial cells.
The first description and naming took place in 1985.
Laboratory tests are hampered by difficulties in growing. Therefore microscopic procedures predominated initially (the spores are up to 1.6 micrometers in size). In the meantime, cell cultures can be created by taking potential host cells by aspiration or biopsy and placing them on a monolayer of kidney cells from western green monkeys . Then the inoculation takes place , whereupon spores form within a few weeks. For the examination of stool samples , however, microscopic methods with the aid of fluorescent dye are easier and faster and are therefore preferred.
The organism is a eukaryote , but it has neither mitochondria nor ribosomes . Like other microspora , a pile thread establishes contact between an Enterocytozoon spore and the host cell, allowing the cytoplasm to penetrate the host cell . Daughter nuclei of the intruder can then arise via merogony . This replication is followed by the cladding of the new core material, i.e. H. the formation of the new spores. The pile thread has a certain number of polar filament turns, which is a distinguishing feature of other Microspora species.
clinic
Animals, for example pigs (often there; causing self-limiting diarrhea ), come into consideration as hosts . Since the organism has also been detected in water ditches, a faecal-oral transmission route via liquid manure is obvious. Of the people, immunocompromised persons are susceptible (there they cause cholangitis or gallbladder inflammation or intestinal infections with diarrhea and rarely respiratory infections). Until the spread of AIDS , this parasite had little spread in humans.
One starting point for treatment is the biosynthesis of chitin , so that albendazole and fumagillin come into question.
literature
- Heinz Rinder: Investigations on diagnostics and the pathogen reservoir of Enterocytozoon bieneusi, 2000
- Bianca Dengjel: On the molecular biological detection and host range of Enterocytozoon bieneusi (Microspora: Enterocytozoonidae), 2001
- Reinthaler u. a .: Epidemiology and Diagnostics, 1993 (PDF; 2.6 MB)
Individual evidence
- ^ I. Desportes, Y. Le Charpentier, A. Galian, F. Bernard, B. Cochand-Priollet, A. Lavergne, P. Ravisse, R. Modigliani: Occurrence of a new microsporidan: Enterocytozoon bieneusi ng, n. Sp. , in the enterocytes of a human patient with AIDS. In: The Journal of Protozoology. 32 (2) 1985, pp. 250-254.
- ^ Marianne Abele-Horn: Antimicrobial Therapy. Decision support for the treatment and prophylaxis of infectious diseases. With the collaboration of Werner Heinz, Hartwig Klinker, Johann Schurz and August Stich, 2nd, revised and expanded edition. Peter Wiehl, Marburg 2009, ISBN 978-3-927219-14-4 , p. 292 f.
- ↑ Burton J. Bogitsh, Clint E. Carter, Thomas N. Oeltmann: Human parasitology. Academic Press, 2005, ISBN 0-12-088468-2 , p. 78.