|1: 1 mixture of ( R ) -form (left) and ( S ) -form (right)|
|External identifiers / databases|
|Mechanism of action|
almost insoluble in water (1.86 mg l −1 at 25 ° C)
|As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .|
The active ingredient occupies the histamine binding sites in the body and thus reduces the allergy reaction. It is a potent antagonist (more precisely: an inverse agonist ) at H 1 receptors (H 1 antihistamine) and does not penetrate the blood-brain barrier . The drug is also mast cell stabilizing .
Medicinal products contain the medicinal substance as a racemate (1: 1 mixture of enantiomers ), with the use of the enantiomer which is more effective or which has fewer side effects would be preferred for fundamental reasons.
Epinastin is commercially available in Germany, Austria and Switzerland under the name Relestat .
- Entry on epinastine in the DrugBank of the University of Alberta .
- The Merck Index. An Encyclopaedia of Chemicals, Drugs and Biologicals . 14th edition, 2006, pp. 617-618, ISBN 978-0-911910-00-1 .
- Data sheet Epinastine hydrochloride ≥ 98% (HPLC), solid from Sigma-Aldrich , accessed on March 30, 2011 ( PDF ).
- EJ Ariëns, Stereochemistry, a basis for sophisticated nonsense in pharmacokinetics and clinical pharmacology , European Journal of Clinical Pharmacology 26 (1984) 663-668, PMID 6092093 .