Eva-Maria Mandelkow

Eva-Maria Mandelkow is a German physician and Alzheimer's researcher.

Career

Eva Mandelkow studied medicine in Heidelberg and Hamburg . After three years of work at the university clinics in both cities and in New Orleans , she began a doctoral thesis at the Max Planck Institute for Medical Research in Heidelberg on the subject of enzyme kinetics of the motor protein myosin , which she completed in 1973 with a doctorate in biochemistry .

From 1974 to 1975 she was a postdoctoral fellow at Brandeis University in Waltham (Massachusetts) , where she did research on cytoskeletal proteins . She continued to work in this area after her return to the Max Planck Institute for Medical Research and during research stays at the Scripps Research Institute in La Jolla and at the Laboratory of Molecular Biology in Cambridge , England.

In 1986 she and her husband, the physicist Eckhard Mandelkow , moved to the Max Planck Working Groups for Structural Molecular Biology at the German Electron Synchrotron DESY in Hamburg .

Eva-Maria Mandelkow heads a working group at the German Center for Neurodegenerative Diseases and the caesar Research Center that deals with cell and animal models of neurodegeneration. Her husband is a group leader at the same institute.

Services

Eva-Maria Mandelkow has made significant contributions to research into neurodegenerative diseases , especially Alzheimer's disease . In collaboration with her husband, she has been researching the role of tau protein in the development of Alzheimer's since the 1990s .

honors and awards

The Hans and Ilse Breuer Foundation awarded Eva-Maria Mandelkow her research award in 2007.

In 2010 Eva-Maria and Eckhard Mandelkow received the MetLife Foundation Award for Medical Research in Alzheimer's Disease ; the award is endowed with USD 125,000 per person. It was awarded to the research couple for investigations into the pathological folding of the tau protein that is typical of Alzheimer's disease , the formation of neurofibrillar aggregates from such folded proteins and the development of inhibitors for this abnormal aggregation with the aim of developing treatment methods.

The American Academy of Neurology gave Eva-Maria and Eckhard Mandelkow in 2011 together with the medical Dennis Dickson from the Mayo Clinic in Jacksonville (Florida) , endowed with $ 100,000 Potamkin Prize for Alzheimer's research. The Mandelkows received the award for results obtained from experiments with mice on the toxicity of tau protein in various dementia diseases.

In 2013, the Mandelkow couple received the Khalid Iqbal Lifetime Achievement Award from the US Alzheimer's Association for life's work .

Individual evidence

1. ^ ^{A b} Eva Mandelkow - Molecular Neurodegeneration, 10-12 September 2013, Cannes, France. (No longer available online.) In: conf.molecularneurodegeneration.com. Archived from the original on April 14, 2015 ; accessed on April 10, 2015 . Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice.   
2. ↑ ^{a b c} U.S. and German scientists honored with Metlife foundation awards for medical research in Alzheimer's disease. Metropolitan Life Insurance Company , February 25, 2010, accessed April 10, 2015 .  
3. ↑ Dr. Eva-Maria Mandelkow & Prof. Dr. Eckhard Mandelkow. German Center for Neurodegenerative Diseases , accessed April 7, 2015 .  
4. ^ ^{A b} Dustin Grunert: Eva-Maria and Eckhard Mandelkow: Two lives for Alzheimer's research . In: Deutsches Ärzteblatt . tape 110 , no. 31-32 , August 5, 2013, pp. A-1497 / B-1319 / C-1303 .
5. ↑ Research Prize - Winner: Prof. Dr. Eva-Maria Mandelkow. Hans and Ilse Breuer Foundation , accessed on April 10, 2015 .  
6. ↑ Three Researchers Awarded $ 100,000 Potamkin Prize from AAN. American Academy of Neurology , accessed April 7, 2015 : “Eva Maria Mandelkow and Eckhard Mandelkow received the Potamkin Prize for their research discoveries in mouse trials that shed new light on the reasons why Tau protein can act as a toxic agent in the development of several dementias. "  
7. ↑ Alzheimer's mice: memory loss due to tau proteins is reversible. Max Planck Society , February 15, 2011, accessed April 7, 2015 .  
8. ↑ Pioneers of Alzheimer's research: Bonn couple is honored for their life's work. Eva-Maria and Eckhard Mandelkow receive an award from the American Alzheimer's Society. German Center for Neurodegenerative Diseases , July 15, 2013, accessed April 10, 2015 .