Eckhard Mandelkow

from Wikipedia, the free encyclopedia

Eckhard Mandelkow (born July 5, 1943 in Łódź , then Litzmannstadt) is a German physicist . His work focuses on molecular structure analysis and research into neurodegenerative diseases , in particular Alzheimer's disease .

Career

Mandelkow studied physics from 1964 to 1969 in Braunschweig , New Orleans and Hamburg . After completing a diploma thesis in the field of high energy physics , he moved to the Max Planck Institute for Medical Research in Heidelberg. In 1973 he received his doctorate in biophysics from the University of Heidelberg with a thesis on the structure of virus proteins. From 1974 to 1976 he was a postdoctoral fellow at Brandeis University in Waltham (Massachusetts) and studied microtubules and other polymers of the cytoskeleton .

In 1977 he returned from the USA to the Max Planck Institute for Medical Research and worked there as a research assistant until 1985. In 1981 he also obtained his habilitation in Heidelberg .

In 1986 he became director of the “Cytoskeleton” working group and spokesman for the Max Planck working groups for structural molecular biology at the German Electron Synchrotron DESY in Hamburg and, in 1999, a scientific member of the Max Planck Society .

Since 2011, Eckhard Mandelkow has headed the working group “Structural principles of neurodegeneration” at the German Center for Neurodegenerative Diseases and the caesar research center ; His wife, the physician Eva-Maria Mandelkow , is a group leader at the same institute .

Services

Mandelkow has made significant contributions in the field of structural biology and crystal structure analysis , in particular for research into neurodegenerative diseases , in particular Alzheimer's disease . In collaboration with his wife, Mandelkow has been studying the role of the tau protein in the development of Alzheimer's since the 1990s .

Honors, awards and memberships

In 2010 Eva-Maria and Eckhard Mandelkow received the MetLife Foundation Award for Medical Research in Alzheimer's Disease ; the award is endowed with USD 125,000 per person. It was awarded to the research couple for investigations into the pathological folding of the tau protein that is typical of Alzheimer's disease , the formation of neurofibrillar aggregates from such folded proteins and the development of inhibitors for this abnormal aggregation with the aim of developing treatment methods.

The American Academy of Neurology gave Eva-Maria and Eckhard Mandelkow in 2011 together with the medical Dennis Dickson from the Mayo Clinic in Jacksonville (Florida) , endowed with $ 100,000 Potamkin Prize for Alzheimer's research. The Mandelkows received the award for results obtained from experiments with mice on the toxicity of tau protein in various dementia diseases.

In 2013, the Mandelkow couple received the Khalid Iqbal Lifetime Achievement Award from the US Alzheimer's Association for life's work .

Eckhard Mandelkow is a member of the Foundation Board of the VERUM Foundation .

Individual evidence

  1. ↑ a b Eckhard Mandelkow. Elbe-studios.de, accessed on April 7, 2015 .
  2. ^ A b c Dustin Grunert: Eva-Maria and Eckhard Mandelkow: Two lives for Alzheimer's research . In: Deutsches Ärzteblatt . tape 110 , no. 31-32 , August 5, 2013, pp. A-1497 / B-1319 / C-1303 .
  3. ↑ a b Prof. Dr. Eckhard Mandelkow. Universitätsklinikum Hamburg-Eppendorf , December 7, 2009, accessed on April 6, 2015 (also contains a list of the most important publications).
  4. ↑ a b U.S. and German scientists honored with Metlife foundation awards for medical research in Alzheimer's disease. Metropolitan Life Insurance Company , February 25, 2010, accessed April 10, 2015 .
  5. ↑ Dr. Eva-Maria Mandelkow & Prof. Dr. Eckhard Mandelkow. German Center for Neurodegenerative Diseases , accessed April 7, 2015 .
  6. ↑ a b Board of Trustees. VERUM Foundation , accessed on April 11, 2015 .
  7. ↑ Three Researchers Awarded $ 100,000 Potamkin Prize from AAN. American Academy of Neurology , accessed April 7, 2015 : “Eva Maria Mandelkow and Eckhard Mandelkow received the Potamkin Prize for their research discoveries in mouse trials that shed new light on the reasons why Tau protein can act as a toxic agent in the development of several dementias. "
  8. ↑ Alzheimer's mice: memory loss due to tau proteins is reversible. Max Planck Society , February 15, 2011, accessed April 7, 2015 .
  9. ↑ Pioneers of Alzheimer's research: Bonn couple is honored for their life's work. Eva-Maria and Eckhard Mandelkow receive an award from the American Alzheimer's Society. German Center for Neurodegenerative Diseases , July 15, 2013, accessed April 10, 2015 .
personal data
SURNAME Mandelkow, Eckhard
BRIEF DESCRIPTION German physicist
DATE OF BIRTH July 5, 1943
PLACE OF BIRTH Litzmannstadt