Francis V. Chisari

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Francis Vincent Chisari (* 5. April 1942 in New York City ) is an American physician ( virology , immunology ), in particular, handles virus-host interaction in hepatitis B and C employed.

Chisari studied at Fordham University (bachelor's degree in 1963) and was 1968 in medicine at Weill Medical College of Cornell University doctorate (M. D. degree). As a post-graduate student , he was a fellow in anatomical pathology at the Mayo Clinic (Graduate School) and a researcher in experimental pathology at the National Institutes of Health at Bethesda. From 1972 to 1973 he completed his residency in internal medicine at Dartmouth Medical School . He was also at the Pasteur Institute. He is Professor and Head of the Experimental Pathology Department at the Scripps Research Institute in La Jolla (Faculty of Molecular and Experimental Medicine), where he has been since 1973. He is an adjunct professor of pathology at the University of California, San Diego .

Chisari made important contributions to immunology and pathology of hepatitis B and C virus infections, for example in the characterization of the immune response of CD4 and CD8 - T cells for hepatitis viruses. He developed the first transgenic mouse model for pathogenic viruses (hepatitis B). He showed that and how chronic hepatitis triggers liver cancer (whereby an overproduction of a protein in the virus envelope plays a special role). His group also showed that cytotoxic T lymphocytes (CTL) secrete substances ( cytokines ) that prevent the virus from multiplying in the liver cell without killing the cell. His research also resulted in various approaches for immunotherapy for (chronic) hepatitis, for example using the body's own activated dendritic cells .

In 1997 he received the Ernst Jung Prize , in 1999 the Rous-Whipple Award from the American Society for Investigative Pathology and the Distinguished Achievement Award from the American Association for the Study of Liver Diseases. He is a member of the Institute of Medicine and the National Academy of Sciences . In 1996 he was elected a Fellow of the American Association for the Advancement of Science .

He holds several patents on various antigens of hepatitis B and C viruses.

Web links

Individual evidence

  1. ↑ Life data according to American Men and Women of Science , Thomson Gale 2004.
  2. ↑ Laudation for the Rous-Whipple Award. (There is a typo in the title.)
personal data
SURNAME Chisari, Francis V.
ALTERNATIVE NAMES Chisari, Francis Vincent (full name)
BRIEF DESCRIPTION American Medical Scientist (Virology, Immunology)
DATE OF BIRTH April 5, 1942
PLACE OF BIRTH New York City