Frederick Alt

Frederick Wayne Alt (* 1949 ; often shortened to Fred Alt ) is an American geneticist and immunologist at Harvard Medical School and Boston Children's Hospital in Boston , Massachusetts .

Life

Alt earned a bachelor's degree from Brandeis University and a Ph.D. in 1977 from Robert Schimke at Stanford University. , each in biology . As a postdoctoral fellow , he worked with David Baltimore at the Massachusetts Institute of Technology (MIT). From 1982 to 1991 he was a professor at Columbia University in New York City before moving to Harvard.

Alt is now (as of 2014) Professor of Pediatrics at Boston Children's Hospital and Professor of Genetics at Harvard Medical School . He has been Scientific Director of the Immune Disease Institute at Harvard Medical School since 2010 . Alt has also been doing research for the Howard Hughes Medical Institute (HHMI) since 1987 .

Act

Alt was able to do fundamental work to elucidate the mechanisms of genomic rearrangements ( recombination ) in cells of the immune system and cancer cells . For the immune system, this applies in particular to research into the system of V (D) J recombination in maturing B cells as well as class switch recombination (CSR, class change ) and somatic hypermutation in mature B cells.

Further work deals with the role of Myc and nuclear oncogenes in tumorigenesis, with the role of gene amplification in connection with drug resistance (see Multiple Drug Resistance ) and oncogenesis, and with genomic stability in mice and human cancer cells.

Awards (selection)

• 1994 member of the American Academy of Arts and Sciences
• 1994 member of the National Academy of Sciences
• 1999 Associate member of the European Molecular Biology Organization
• 2004 Pasarow Foundation Award
• 2009 William B. Coley Award (together with Klaus Rajewsky )
• 2010 Fellow of the American Association for the Advancement of Science
• 2012 Kornberg-Berg Award
• 2014 Rosenstiel Award
• 2015 Szent-Györgyi Prize

The Cancer Research Institute in New York has presented the Frederick W. Alt Award for New Discoveries in Immunology since 2007 .

Web links

• Frederick Alt at Harvard Medical School (hms.harvard.edu)
• Frederick W. Alt, PhD at Dana Farber / Harvard Cancer Center (dfhcc.harvard.edu)
• Alt Lab at the Immune Disease Institute of Harvard Medical School (idi.harvard.edu)
• Frederick W. Alt, Ph.D. at Harvard Medical School Department of Genetics (med.harvard.edu)
• Frederick W. Alt, PhD and Research Summary at the Howard Hughes Medical Institute (hhmi.org)

Individual evidence

1. ↑ Book of Members (PDF, 524 kB) of the American Academy of Arts and Sciences (amacad.org); accessed on October 15, 2014.
2. ↑ Frederick W. Alt at the National Academy of Sciences (nasonline.org); accessed on October 15, 2014.
3. ↑ EMBO Membership Pocket Guide 2012 (PDF, 430 kB) at the European Molecular Biology Organization (embo.org); accessed on October 16, 2014.
4. ^ William B. Coley Award at the Cancer Research Institute (cancerresearch.org); accessed on October 15, 2014.
5. ^ Fellows of the AAAS: Frederick Alt. (No longer available online.) American Association for the Advancement of Science, formerly original ; accessed on January 23, 2018 .  ( Page no longer available , search in web archives )  Info: The link was automatically marked as defective. Please check the link according to the instructions and then remove this notice.    
6. ↑ https://med.stanford.edu/alumni/events/kornberg-berg-award.html
7. ↑ Rosenstiel Award - Current Winner at Brandeis University (brandeis.edu); accessed on October 15, 2014.
8. ^ Frederick W. Alt Award at the Cancer Research Institute (cancer research.org); accessed on October 16, 2014.