Gliadorphin
| Gliadorphin | ||
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| other names |
L -Tyrosyl- L -prolyl- L -glutaminyl- L -prolyl- L -glutaminyl- L -prolyl- L -phenylalanine ( IUPAC ) |
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| Mass / length primary structure | 875.98 Da | |
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Gliadorphin , also referred to as gluteomorphin in some publications , is an exogenous opioid peptide , a so-called exorphin , which can be produced during the digestion of gliadin contained in gluten .
structure
Gliadorphin is a seven amino acids existing heptapeptide . The amino acid sequence is Tyr - Pro - Gln -Pro-Gln-Pro- Phe (in the one -letter code : YPQPQPF). The empirical formula is C 43 H 57 N 9 O 11 and the molar mass is 875.4 g · mol −1 .
effect
Normally, like other peptides, gliadorphine is completely broken down during digestion by digestive enzymes . This also applies to other exogenous opioid peptides, such as casomorphine in milk . There is some evidence that a gluten-free diet significantly alleviates symptoms in autistic children. These children may lack the enzymes to completely break down gluten in the body. Furthermore, it is assumed that the incompletely broken down exorphins then bind to the corresponding opioid receptors in the brain of the affected children and develop their opioid effect there. This hypothesis is the basis for the Gfcf diet ( gluten-free casein-free diet = gluten- and casein-free diet). The topic is discussed very controversially in professional circles.
See also
literature
- Kitts DD, Weiler K: Bioactive proteins and peptides from food sources. Applications of bioprocesses used in isolation and recovery . In: Curr. Pharm. Des. . 9, No. 16, 2003, pp. 1309-23. PMID 12769739 .
- Yoshikawa M, Takahashi M, Yang S: Delta opioid peptides derived from plant proteins . In: Curr. Pharm. Des. . 9, No. 16, 2003, pp. 1325-30. PMID 12769740 .
- Zioudrou C, Streaty RA, Klee WA: Opioid peptides derived from food proteins. The exorphins . In: J. Biol. Chem. . 254, No. 7, April 1979, pp. 2446-9. PMID 372181 .
Web links
Individual evidence
- ↑ GW Christison, K.Ivany: Elimination diets in autism spectrum disorders: any wheat amidst the chaff? In: J Dev Behav Pediatr , 27/2006, pp. 162-171, PMID 16685183 .