Rubiscoline

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The Rubiscoline are a group of opioid peptides that result from the digestion of the protein ribulose-1,5-bisphosphate-carboxylase / -oxygenase ( RuBisCo ) of spinach leaves .

Mode of action

The Rubiscoline mimic the effects of opioids , which is why they are psychologically active. They are very similar to the gluten exorphins ( gliadorphins ). Their influence on the mental state is not yet fully clarified, or it is discussed very controversially (see Gfcf nutrition ). The Rubiscoline bind to the δ-opioid receptor and have an analgesic (pain-relieving) effect. They also stimulate memory formation . In 2007, anti- anxiety properties of Rubiscolin-6 were found in animal models .

Types of Rubiscoline

Two types of rubiscolines are known so far.

Rubiscolin-5

Rubiscolin-6

  • Peptide sequence: H-Gly-Tyr-Tyr-Pro- Thr -OH
  • Molecular formula: C 39 H 54 N 6 O 10
  • Molar mass: 766.87 g mol −1

Individual evidence

  1. ↑ Yang S, including: Rubiscolin, a delta selective opioid peptide derived from plant Rubisco . In: FEBS Lett . . 509, No. 2, 2001, pp. 213-7. PMID 11741591 .
  2. ↑ Yang S, Kawamura Y, Yoshikawa M: Effect of rubiscolin, a delta opioid peptide derived from Rubisco, on memory consolidation . In: Peptides . 24, No. 2, 2003, pp. 325-8. PMID 12668220 .
  3. ↑ Hirata H, Sonoda S, Agui S, Yoshida M, Ohinata K, Yoshikawa M: Rubiscolin-6, a delta opioid peptide derived from spinach Rubisco, has anxiolytic effect via activating sigma 1 and dopamine D 1 receptors . In: Peptides . 28, No. 10, 2007, pp. 1998-2003. doi : 10.1016 / j.peptides.2007.07.024 . PMID 17766012 .

literature

  • S. Doltsinis, W. Andlauer: Alternatives to animal proteins: key components of food. In: Chemistry in our time , 38/2004, pp. 182–9.

See also