Glutathione transferase omega
| Glutathione transferase omega | ||
|---|---|---|
| Mass / length primary structure | 241/243 amino acids | |
| Secondary to quaternary structure | Homodimer | |
| Identifier | ||
| Gene name (s) | GSTO1 , GSTO2 | |
| External IDs | ||
| Enzyme classification | ||
| EC, category | 2.5.1.18 , transferase | |
| Occurrence | ||
| Parent taxon | Mammals, insects, worms | |
Glutathione transferases omega (GSTO) are enzymes in mammals, insects and worms that can reduce dehydroascorbic acid and monomethyl arsenate with the help of glutathione . They therefore play an important role in the recycling of vitamin C and in the biotransformation of arsenic compounds . Two paralogues are known in humans , which are encoded by the genes GSTO1 and GSTO2 . GSTO-1 occurs in the cytoplasm of all tissue types, but especially in the liver , skeletal muscles and in the heart . GSTO-2 is also produced everywhere, but especially in the testes .
The GSTO belong to the group of glutathione-S-transferases and are characterized by the fact that a cysteine residue acts as the catalytic center and by their dehydroascorbate reductase activity.
Other functions of GSTO-1 that have been discovered are modulation of the ryanodine receptor and interaction with drugs that inhibit the release of cytokines .
There may be variants of GSTO-1 associated with amyotrophic lateral sclerosis , others may increase the risk of breast cancer , and others may be associated with cerebral atherosclerosis . GSTO-1 is a possible candidate as the cause of the platinum resistance phenomenon .
Catalyzed reactions
+ 2 GSH + GSSG 
Dehydroascorbic acid is reduced to ascorbic acid, while glutathione is oxidized to glutathione disulfide.
Individual evidence
- ↑ UniProt P78417
- ^ A b c Whitbread AK, Masoumi A, Tetlow N, Schmuck E, Coggan M, Board PG: Characterization of the omega class of glutathione transferases . In: Meth. Enzymol. . 401, 2005, pp. 78-99. doi : 10.1016 / S0076-6879 (05) 01005-0 . PMID 16399380 .
- ^ Van de Giessen E, Fogh I, Gopinath S, et al : Association study on glutathione S-transferase omega 1 and 2 and familial ALS . In: Amyotroph Lateral Scler . 9, No. 2, April 2008, pp. 81-4. doi : 10.1080 / 17482960701702553 . PMID 18427999 .
- ↑ Olsen A, Autrup H, Sørensen M, Overvad K, Tjønneland A: Polymorphisms of glutathione S-transferase A1 and O1 and breast cancer among postmenopausal Danish women . In: Eur J Cancer Prev . 17, No. 3, June 2008, pp. 225-9. doi : 10.1097 / CEJ.0b013e3282b6fe1e . PMID 18414193 .
- ↑ Kölsch H, Larionov S, Dedeck O, et al : Association of the glutathione S-transferase omega-1 Ala140Asp polymorphism with cerebrovascular atherosclerosis and plaque-associated interleukin-1 alpha expression . In: Stroke . 38, No. 10, October 2007, pp. 2847-50. doi : 10.1161 / STROKEAHA.107.484162 . PMID 17717316 .
- ↑ Yan XD, Pan LY, Yuan Y, Lang JH, Mao N: Identification of platinum-resistance associated proteins through proteomic analysis of human ovarian cancer cells and their platinum-resistant sublines . In: J. Proteome Res . 6, No. 2, February 2007, pp. 772-80. doi : 10.1021 / pr060402r . PMID 17269733 .
- ↑ D'Eustachio / reactome.org: Reduction of dehydroascorbate to ascorbate ( page no longer available , search in web archives ) Info: The link was automatically marked as defective. Please check the link according to the instructions and then remove this notice. .
