Granuloma facial

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Classification according to ICD-10
L92.2 Granuloma faciale [Granuloma eosinophilicum faciei]
ICD-10 online (WHO version 2019)
Granuloma faciale on a patient's nose

The granuloma faciale , even granuloma eosinophilicum faciei or eosinophilic granuloma of the face called, is a chronic persistent inflammatory skin disease of unknown cause . The granuloma faciale is characterized by well-circumscribed, asymptomatic, erythematous spots or nodules that appear almost exclusively on the face.

Description and diagnosis

The granuloma faciale described for the first time in 1945 by the Australian dermatologist John Edwin Mackonochie Wigley (1892–1962) is a chronic inflammation of the skin that usually occurs on the nose , chin , forehead , temples or cheeks . The disease is characterized by an increase in the number of eosinophilic granulocytes ( eosinophilia ) and cutaneous leukocytoclastic angiitis (leukocytoclastic vasculitis). She is benign . The granuloma faciale can occur at any age, preferably in males. It is usually round or oval, with a brownish-red surface that has large follicular pores that are reminiscent of orange peel .

therapy

Various treatment methods for granuloma faciale have been described. For example, medication by means of the local administration of tacrolimus or the oral administration of dapsone (approx. 100 to 200 mg per day for four months). The intralesional injection of long-acting glucocorticoids , such as triamcinolone , is also a treatment option.

If conservative treatment methods fail, the granuloma faciale can be removed, for example, by cryosurgery , cauterization or laser irradiation ( argon-ion laser , dye laser or CO 2 laser ).

Individual granuloma faciale can also be treated by excision .

forecast

The granuloma faciale has a chronic course and occasionally it heals spontaneously with scarred atrophy.

further reading

  • SA Holme, P. Laidler, PJ Holt: Concurrent granuloma faciale and eosinophilic angiocentric fibrosis. In: British Journal of Dermatology Volume 153, Number 4, October 2005, pp. 851-853. doi: 10.1111 / j.1365-2133.2005.06864.x . PMID 16181479 . (Review).
  • J. Narayan, AG Douglas-Jones: Eosinophilic angiocentric fibrosis and granuloma faciale: analysis of cellular infiltrate and review of literature. In: The Annals of Otology, Rhinology, and Laryngology. Volume 114, Number 1 Pt 1, January 2005, pp. 35-42. PMID 15697160 . (Review).
  • PE LeBoit: Granuloma faciale: a diagnosis deserving of dignity. In: The American Journal of Dermatopathology Volume 24, Number 5, October 2002, pp. 440-443. PMID 12357207 . (Review).
  • I. Inanir, Y. Alvur: Granuloma faciale with extrafacial lesions. In: The British journal of dermatology. Volume 145, Number 2, August 2001, pp. 360-362. PMID 11531816 . (Review).
  • G. Roustan, E. Sánchez Yus, C. Salas, A. Simón: Granuloma faciale with extrafacial lesions. In: Dermatology Volume 198, Number 1, 1999, pp. 79-82. PMID 10026409 . (Review).

Individual evidence

  1. ↑ a b c d e f g P. Altmeyer, M. Bacharach-Buhles: Encyclopedia of Dermatology, Venereology, Allergology, Environmental Medicine. Springer-Verlag Berlin Heidelberg, 2010.
  2. ↑ J. Thiyanaratnam, SD Doherty, B. Krishnan, S. Hsu: Granuloma faciale: Case report and review. In: Dermatology online journal. Volume 15, Number 12, 2009, p. 3. PMID 20040253 . (Review in Open Access ).
  3. ↑ Orbitury. In: The British medical journal. from August 18, 1962, p. 485. PMC 1925848 (free full text)
  4. ^ JE Wigley: Eosinophilic Granuloma. ? Sarcoid of Boeck. In: Proceedings of the Royal Society of Medicine. Volume 38, Number 3, January 1945, pp. 125-126. PMID 19992999 . PMC 2181658 (free full text).
  5. ↑ a b c d M. Sand, D. Sand, C. Thrandorf, V. Paech, P. Altmeyer, FG Bechara: Cutaneous lesions of the nose. In: Head & face medicine. Volume 6, 2010, p. 7. doi: 10.1186 / 1746-160X-6-7 . PMID 20525327 . PMC 290354 (free full text). (Review in Open Access ).
  6. ↑ J. Rieker, U. Hengge, T. Ruzicka, D. Bruch-Gerharz: Multifocal Granuloma eosinophilicum faciei - Successful treatment with tropical tacrolimus. In: Der Dermatologist Volume 57, Number 4, April 2006, pp. 324–326. doi: 10.1007 / s00105-006-1112-0 . PMID 16523273 .
  7. ^ C. Patterson, I. Coutts: Granuloma faciale successfully treated with topical tacrolimus. In: Australasian Journal of Dermatology Volume 50, Number 3, August 2009, pp. 217-219. doi: 10.1111 / j.1440-0960.2009.00543.x . PMID 19659988 . (Review).
  8. ↑ PC van de Kerkhof: On the efficacy of dapsone in granuloma faciale. In: Acta Dermato-Venereologica Volume 74, Number 1, January 1994, pp. 61-62. PMID 7908487 .
  9. ↑ C. Vente, R. Rupprecht, E. Oestmann, S. Menzel, C. Neumann: Granuloma eosinophilicum faciei - successful cryosurgical treatment in six patients. In: The dermatologist. Volume 49, number 6, pp. 477-481, doi: 10.1007 / s001050050773 . PMID 9675575
  10. ↑ T. Fikrle, K. Pizinger: Granuloma Faciale treated with 595-nm pulsed dye laser. In: Dermatologic Surgery Volume 37, Number 1, January 2011, pp. 102-104. doi: 10.1111 / j.1524-4725.2010.01823.x . PMID 21070474 .
  11. ↑ WK Chung, GH Park, CH Kim, SE Chang, MW Lee, JH Choi, KC Moon, JK Koh: Keloidal granuloma faciale after CO2 laser treatment for melanocytic naevus. In: Journal of the European Academy of Dermatology and Venereology: JEADV. Volume 23, Number 5, May 2009, pp. 611-612, ISSN  1468-3083 . PMID 19415815 .
  12. ↑ RG Wheeland, JR Ashley, DA Smith, DL Ellis, DN Wheeland: Carbon dioxide laser treatment of granuloma faciale. In: Journal of Dermatologic Surgery and Oncology Volume 10, Number 9, September 1984, pp. 730-733. PMID 6434613 .