Guy R. Cornelis
Guy R. Cornelis (born August 25, 1946 in Uccle , Belgium ) is a Belgian microbiologist .
Life
Cornelis studied pharmacy , did research on β-lactamases in Oxford (UK) and received his doctorate in 1974 from Louvain University in Belgium. He examined antibiotic resistance - plasmids in Bristol (GB) as well as transposons at the University of Freiburg (D) and at the Max Planck Institute in Cologne (Germany). After being appointed professor in Louvain in 1984, he began to study bacterial pathogenesis. In 1991 he joined the Christian de Duve Institute in Brussels. In 2001 he took over a professorship for molecular microbiology at the Biozentrum of the University of Basel . Since his retirement in 2011, Cornelis has continued his research at the University of Namur in Belgium.
Act
Guy R. Cornelis deals with the elucidation of complex mechanisms of action of bacterial infectious diseases . Cornelis and H. Wolf-Watz (Umeå, Sweden) received special recognition for their discovery of the bacterial type III secretion system (T3SS). T3SS is a mechanism by which bacteria inject a cocktail of cell toxins, so-called effector proteins, into animal, plant or insect cells. These effectors disarm or reprogram the host cells by sabotaging their cellular signaling network . The T3SS device, also known as the injectisome, is a complex nano-syringe that consists of more than 25 different proteins . Since 2004, Cornelis has been researching Capnocytophaga canimorsus , a bacterium in the dog's mouth that causes fatal infections in humans.
Awards
- 1980: Prize from the Belgian Royal Academy of Medicine
- 1985: Pfizer Prize
- 1993: Member of the Belgian Royal Academy of Medicine
- 1998: elected member of the European Molecular Biology Organization (EMBO)
- 2008: Member of the American Academy for Microbiology (AAM)
Publications (selection)
- T. Michiels, P. Wattiau, R. Brasseur, JM Ruysschaert, G. Cornelis: Secretion of Yop proteins by Yersiniae. In: Infection and Immunity . Volume 58, Number 9, September 1990, pp. 2840-2849, ISSN 0019-9567 . PMID 2129533 . PMC 313576 (free full text).
- MP Sory, GR Cornelis: Translocation of a hybrid YopE-adenylate cyclase from Yersinia enterocolitica into HeLa cells. In: Molecular microbiology. Volume 14, Number 3, November 1994, pp. 583-594, ISSN 0950-382X . PMID 7885236 .
- P. Wattiau, B. Bernier, P. Deslée, T. Michiels, GR Cornelis: Individual chaperones required for Yop secretion by Yersinia. In: Proceedings of the National Academy of Sciences . Volume 91, Number 22, October 1994, pp. 10493-10497, ISSN 0027-8424 . PMID 7937981 . PMC 45047 (free full text).
- L. Journet, C. Agrain, P. Broz, GR Cornelis: The needle length of bacterial injectisomes is determined by a molecular ruler. In: Science. Volume 302, Number 5651, December 2003, pp. 1757-1760, ISSN 1095-9203 . doi : 10.1126 / science.1091422 . PMID 14657497 .
- CA Mueller, P. Broz, SA Müller, P. Ringler, F. Erne-Brand, I. Sorg, M. Kuhn, A. Engel, GR Cornelis: The V-antigen of Yersinia forms a distinct structure at the tip of injectisome needles. In: Science. Volume 310, Number 5748, October 2005, pp. 674-676, ISSN 1095-9203 . doi : 10.1126 / science.1118476 . PMID 16254184 .
Web links
- Website Biozentrum, Emeriti
- Biozentrum of the University of Basel
- University of Basel
- ERC Advanced Investigator Grant
- Bacteria hoard dog mouth
Individual evidence
- ^ University of Namur, Vita Cornelius Guy
- ↑ Research Group Guy R Cornelis ( Memento of the original from November 5, 2013 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice.
| personal data | |
|---|---|
| SURNAME | Cornelis, Guy R. |
| BRIEF DESCRIPTION | Belgian microbiologist |
| DATE OF BIRTH | August 25, 1946 |
| PLACE OF BIRTH | Uccle , Belgium |