Hans Dieter Ochs

Hans Dieter Ochs , also Hansdieter Ochs , (born September 29, 1936 in Spaichingen ) is an immunologist and pediatrician . He is Professor in the Department of Pediatrics, Division of Immunology, Infectious Diseases and Rheumatology, University of Washington School of Medicine, Seattle .

Life and research

Hans D. Ochs received his doctorate from the Albert-Ludwigs-Universität Freiburg and was postgraduate at the Kapiolani Medical Center for Women & Children, Honolulu and the Eberhard Karls Universität Tübingen . In 1956 in Tübingen he became a member of the Catholic student association AV Guestfalia Tübingen in the CV . He is approved by the German Society for Child and Adolescent Medicine as well as the American Board of Pediatrics and American Board of Allergy and Immunology.

Hans D. Ochs explores the molecular basis of primary immunodeficiency diseases with a special interest for genes associated with Wiskott-Aldrich syndrome , hyper-IgM syndrome , X-linked agammaglobulinemia, IPEX syndrome and autosomal dominant hyper-IgE syndrome are associated . To improve the long-term consequences of these diseases, he has actively participated in clinical trials to develop strategies for immunoglobulin replacement therapy , hematopoietic stem cell transplantation, and gene therapy .

Ochs' clinical interest focuses on the intravenous and subcutaneous use of immunoglobulin in patients with antibody deficiencies and the in vivo analysis of antibody production using the bacteriophage Phi X 174. He and his colleagues also contributed to the identification of several genes that are responsible for the X -Chromosome Localized Primary Immunodeficiency Diseases are responsible, including CD40L, Wiskott-Aldrich Syndrome Protein, Buttons Tyrosine Kinase, and FOXP3 .

Recently, his focus has been on the uracil DNA glycosylase gene, which causes a rare form of autosomal recessive hyper-IgM syndrome, and on STAT3, which, when mutated, leads to autosomal dominant hyper-IgE syndrome .

In 1995, he moved the University of Washington 's Immunodeficiency Clinic to Seattle Children's Hospital to provide diagnostic evaluations and clinical treatments for both children and adult patients with primary immunodeficiency disorders. He initiated and also maintains a successful collaboration with the Center for Bone Marrow Transplantation of the Fred Hutchinson Cancer Research Center since the early 1970s and participated in the creation of transplantation protocols for patients with SCID , Wiskott-Aldrich syndrome , Chronic Granulomatous Disease ( septic granulomatosis ) and hyper-IgM syndrome.

The Ochs / Torgerson Laboratory at Seattle Children's Hospital focuses on:

Autoimmunity and Immune Dysregulation
Regulatory T cells and mutations of FOXP3
Molecular consequences of heterozygous dominant-negative STAT3 mutations and their relationship to autosomal dominant hyper-IgE syndrome

Memberships and offices

American Association of Immunology
American Federation for Clinical Research
Society for Pediatric Research
American Pediatric Society
Clinical Immunology Society
European Society of Immune Deficiencies

He serves on the committees of the Immune Deficiency Foundation, Jeffrey Modell Foundation, US Immunodeficiency Network (USIDNET), and International Union of Immunological Societies (IUIS). Hans D. Ochs is also a founding member of the USIDNET / Clinical Immunology Society (CIS) Annual Summer School and on the Editorial Board of the Tohoku Journal of Experimental Medicine and Turkish Journal of Medical Sciences.

Publications

with ER Stiehm and Jerry A. Winklestein: Immunologic Disorders in Infants and Children. 5th edition. Saunders, 2004, ISBN 0-7216-8964-7 .
with CI Edvard Smith and Jennifer M. Puck: Primary Immunodeficiency Diseases: A Molecular & Genetic Approach. 2nd Edition. Oxford University Press, 2006, ISBN 0-19-514774-X .

Over 400 publications, also as a co-author in: Blood (Journal of the American Society of Hematology ), Journal of Immunology, European Journal of Immunology, Journal of Pediatrics, Cell Growth & Differentiation, Nature Genetics , Nature Reviews Immunology , Nature Medicine , Journal of Clinical Investigation, Journal of Experimental Medicine , The New England Journal of Medicine , The Lancet , Immunity , Journal of Biological Chemistry , Experimental Haematology, Bone Marrow Transplantation and Journal of Allergy and Clinical Immunology .

Web links

personal data
SURNAME	Ochs, Hans Dieter
ALTERNATIVE NAMES	Ochs, Hansdieter
BRIEF DESCRIPTION	German immunologist
DATE OF BIRTH	September 29, 1936
PLACE OF BIRTH	Spaichingen