Heinrich Reichert

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Heinrich Reichert (2011)

Heinrich Reichert (born September 25, 1949 in Braunau am Inn ; † June 13, 2019 ) was a Swiss developmental and neurobiologist at the Biozentrum of the University of Basel .

Life

Heinrich Reichert studied physics , chemistry and biology at the University of Karlsruhe . After receiving his doctorate in 1979 at the University of Freiburg i. Breisgau in the genetics department , he spent three years researching at Stanford University, California . In 1982 Heinrich Reichert went to the Zoological Institute of the University of Basel. From 1986 to 1991, he did a teaching and research period at the University of Geneva before Heinrich Reichert returned to the University of Basel. Here he was a professor at the Zoological Institute until 2006 and then went to the Biozentrum of the University of Basel, where he has researched and taught ever since.

Act

Using the example of the fruit fly Drosophila, Heinrich Reichert examined the role of neural stem cells in the development of the brain . He discovered a molecular production program according to which these stem cells develop in the brain. A similar, evolutionarily conserved development program is also involved in the formation of the brains in vertebrates .

If the course of the program is disturbed by targeted gene mutations , the stem cells produce , in an uncontrolled manner, incorrectly programmed cells that divide in an uncontrolled manner. The result is the formation of deadly brain tumors . Heinrich Reichert researched in detail how such genetic errors come about in the development of neural stem cells. His goal is to find new strategies to avoid the formation of such brain tumors.

Awards

  • 2000 Neurex founding member and vice president
  • 2005 Scientific member of the European Doctoral School, Strasbourg

List of publications

  • together with Hanns-Christof Spatz , Anton Emanns: Associative learning of Drosophila melanogaster . In: Nature , 248 : 359-361 (1974), ISSN  0028-0836
  • together with Jeffrey J. Wine: Neural mechanisms for serial order in a stereotyped behavior sequence . In: Nature , 196-87 (1982), ISSN  0028-0836
  • together with RM Robertson, KG Pearson: Flight interneurons in the locust and the origin of insect wings . In: Science , 217 : 177-179 (1982), ISSN  0036-8075
  • together with CHF Rowell, C. Griss: Course correction circuitry translates feature detection into behavioral action in locusts . In: Nature , 315 : 142-144 (1985), ISSN  0028-0836
  • together with F. Hirth, S. Therianos, T. Loop, Walter Gehring , Katsuo Furukubo-Tokunaga: Developmental defects in brain segmentation caused by mutations of the homeobox genes orthodenticle and empty spiracles in Drosophila . In: Neuron , Vol. 15 (1995), pp. 769-778, ISSN  0896-6273
  • together with Sandra Leuzinger, F. Hirth, D. Gehrlich, Dario Acampora, Antonio Simeone, Walter Gehring, Robert Finkelstein , Katsuo Furukubo-Tokunaga: Equivalence of the fly orthodenticle gene and the human OTX genes in embryonic brain development of Drosophila . In: Development , Vol. 125 (1998), pp. 1703-1710.
  • together with F. Hirth, Lars Kammermeier, Erich Frei, Uwe Walldorf, Markus Noll: An urbilaterian origin of the tripartite brain. Developmental genetic insights from Drosophila . In: Development , Vol. 130 (2003), pp. 2365-2373.
  • together with Bruno Bello, Natalya Izergina, Emmanuel Caussinus: Amplification of neural stem cell proliferation by intermediate progenitor cells in Drosophila brain development . In: Neural Development , Vol. 3 (2008), pp. 5f, ISSN  1749-8104
  • together with George S. Boyan: Mechanisms for complexity in the brain. Generating the insect central complex . In: Trends in Neuroscience , Vol. 34 (2011), pp. 247-257, ISSN  2211-9493
  • together with Christian Berger, Heike Harzer, Thomas Burkhard, Jonas Steinmann, Suzanne van der Horst, Anne-Sophie Laurenson, Maria Novatchkova, Jürgen Knoblich : Transcriptome analysis of Drosophila neural stem cells reveals a transcriptional network for self-renewal . In: Cell Reports , Vol. 2 (2012), pp. 1-12, ISSN  2211-1247

Web links

Individual evidence

  1. ^ Obituary for Prof. Heinrich Reichert (1949 - 2019). University of Basel, Biozentrum, June 18, 2019, accessed on June 22, 2019 .
  2. ↑ Curriculum Vitae at the Biozentrum, University of Basel ( Memento from March 26, 2016 in the Internet Archive ).
  3. ↑ Heinrich Reichert research group. Biozentrum, University of Basel ( Memento from January 28, 2015 in the Internet Archive ).
personal data
SURNAME Reichert, Heinrich
BRIEF DESCRIPTION Swiss neurobiologist and professor at the Biozentrum of the University of Basel, Switzerland
DATE OF BIRTH September 25, 1949
PLACE OF BIRTH Braunau am Inn
DATE OF DEATH June 13, 2019