Herbert Zimmermann (neuroscientist)

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Herbert Zimmermann (2012)

Herbert Zimmermann (born January 10, 1944 in Chiesch ) is a German neuroscientist .

Life

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Zimmermann studied chemistry, biology and philosophy at the Ludwig Maximilians University in Munich from 1964 to 1969 and received his doctorate from the University of Regensburg in 1971. In the following two years he worked as a postdoctoral fellow in the Department of Biochemistry at the University of Cambridge . From 1973 to 1979 he was a scientist and group leader in the Department of Neurochemistry at the Max Planck Institute for Biophysical Chemistry in Göttingen . From 1980 to 1983 he taught as a professor of neurobiology at the University of Oldenburg . In 1983 he was appointed to a chair for zoology and as head of the department for neurochemistry at the Johann Wolfgang Goethe University in Frankfurt am Main . In 1987 he worked as a visiting professor at the Institute for Brain Research of the Medical Faculty of Tokyo University ( Tokyo Daigaku ). From 1991 to 1995 he was President of the German Neuroscientific Society . After retiring in 2010, he worked in the Department of Molecular and Cellular Neurobiology at the Johann Wolfgang Goethe University. Since 2019 he has been President of the Scientific Society at the Johann Wolfgang Goethe University in Frankfurt am Main .

Scientific activity

The focus of his scientific work was in the field of synaptic transmission and later signal transmission through extracellular nucleotides . In the laboratory of Victor P. Whittaker in Cambridge he began his studies on the dynamics of the synaptic vesicle compartment . He used the electric organ of the electric ray ( Torpedo marmorata ), which is homologous to neuromuscular contacts in mammals , as a model system for the cholinergic synaptic transmission of excitation . He demonstrated that activation of the synapse induces both a morphological and a biochemical heterogeneity of synaptic vesicles. These investigations provided a cell-biological explanation for a previously unsolved problem from the earlier investigation history of synaptic transmission, namely that stimulated nerve endings preferentially release newly synthesized transmitter substance.

Another field of investigation involved the so-called. Purinergic neurotransmission , signal transduction by extracellular nucleotides , such as adenosine triphosphate ( ATP ). The focus of his research was on the biochemical mechanisms by which released nucleotides are broken down into nucleosides . This led to the isolation and molecular cloning of the AMP -hydrolyzing enzyme ecto-5'-nucleotidase as well as a number of nucleoside triphosphate and nucleoside diphosphate hydrolyzing enzymes of the family of the ecto-nucleoside triphosphate diphosphohydrolases. He initiated a new nomenclature for these enzymes and for the ecto-pyrophosphatases / phosphodiesterases.

Most recently, he has conducted studies on the proteome of synaptic vesicles and the role of extracellular nucleotides in controlling adult neurogenesis , the formation of new nerve cells in the adult mammalian brain.

Awards and memberships

  • 2000 Johannes Müller Lecture, Berlin
  • 2006 Geoffrey Burnstock Lecture, Ferrara, Italy
  • 2007 election as corresponding member of the Real Academia Nacional de Farmacia, Spain
  • 2009 elected member of the Academia Europaea
  • 2013 Giuliana Fassina Award from the Italian Purine Club

Publications (selection)

  • with H. Altner: The saccus vasculosus. In: The Structure and Function of Nervous Tissue. Vol. V. Academic Press, New York / London 1972, ISBN 0-19-508293-1 , pp. 293-328.
  • with CR Denston: Recycling of synaptic vesicles in the cholinergic synapses of the Torpedo electric organ during induced transmitter release. In: Neuroscience. 2, pp. 695-714 (1977). PMID 22832
  • with VP Whittaker: Morphological and biochemical heterogeneity of cholinergic synaptic vesicles. In: Nature. Lond. 1977, 267, pp. 633-635. PMID 876386
  • Turnover of adenine nucleotides in cholinergic synaptic vesicles of the Torpedo electric organ. In: Neuroscience. 3: 827-836 (1978).
  • with MJ Dowdall and DA Lane: Purine salvage at the cholinergic nerve endings of the Torpedo electric organ: the central role of adenosine. In: Neuroscience. 4: 979-993 (1979). PMID 552616
  • Vesicle recycling and transmitter release. In: Neuroscience. 4 (1979), pp. 1773-1804. PMID 43485
  • On the vesicle hypothesis. In: Trends Neurosci. 2, pp. 282-285 (1979). doi.org/10.1016/0166-2236(79)90111-5
  • with GW Kreutzberg and M. Reddington (eds.): Cellular Biology of Ectoenzymes. Springer Verlag, Berlin / Heidelberg / New York / Tokyo 1986, ISBN 978-3-642-70666-0 .
  • with EJM Grondal: Purification, characterization and cellular localization of 5'-nucleotidase from Torpedo electric organ. In: Biochem. J. 245: 805-810 (1987). PMID 2822031 ; PMCID: PMC1148201
  • with W. Volknandt, M. Vogel, J. Pevsner, Y. Misumi and Y. Ikehara: 5'-nucleotidase from the electric ray electric lobe. Primary structure and relation to mammalian and procaryotic enzymes. In: Biochem. J. 202: 855-861 (1991). PMID 1765099
  • Synaptic Transmission. Cellular and Molecular Basis. Thieme / Oxford University Press, 1993.
  • with B. Kegel, N. Braun, P. Heine, CR Maliszewski: An ecto-ATPase and an ecto-ATP diphosphohydrolase are expressed in brain. In: Neuropharmacology. 36: 1189-1200 (1997). PMID 9364474
  • with P. Illes (Ed.): Nucleotides and their Receptors in the Nervous System. Elsevier, Amsterdam / New York / Oxford / Tokyo 1999. ISBN 978-0-08-086245-3
  • with N. Braun, S. Fengler, C. Ebeling and J. Servos: Sequencing, functional expression and characterization of rat NTPDase6, a nucleoside diphosphatase and novel member of the ecto-nucleoside triphosphate diphosphohydrolase family. In: Biochem. J. 351 (2000), pp. 639-647. PMID 11042118 ; PMCID: PMC1221403
  • with SK Mishra, N. Braun, V. Shukla, M. Füllgrabe, C. Schomerus, H.-W. Korf, C. Gachet, Y. Ikehara, J. Sévigny and SC Robson: Extracellular nucleotide signaling in adult neural stem cells: synergism with growth factor-mediated cellular proliferation. In: Development. 133 (2006), pp. 675-684. PMID 16436623 ; doi: 10.1242 / dev.02233
  • with J. Burré, T. Beckhaus, H. Schägger, C. Corvey, S. Hofmann, M. Karas and W. Volknandt: Analysis of the synaptic vesicle proteome using three gel-based protein separation techniques. In: Proteomics. 6 (2006), pp. 6250-6262. PMID 17080482 ; doi: 10.1002 / pmic.200600357

Web links

Individual evidence

  1. ↑ H. Zimmermann: Vesicle recycling and transmitter release . In: Neuroscience . 4, No. 12, 1979, pp. 1773-1804.
  2. ^ RL Klein, H. Lagercrantz, H. Zimmermann (Ed.): Neurotransmitter Vesicles. Academic Press, London / New York 1982, ISBN 0-12-413680-X , p. 305.
  3. ↑ H. Zimmermann, M. Zebisch, N. Sträter: Cellular function and molecular structure of ecto-nucleotidases. In: Purinergic Signal . 8.3 2012, pp. 437-502.
  4. ↑ L. Vanduffel, R. Lemmens (Ed.): Ecto-ATPases and related ectonucleotidases. Shaker Publishing BV, Maastricht 2000, ISBN 90-423-0060-4 , p. 1.
personal data
SURNAME Carpenter, Herbert
BRIEF DESCRIPTION German neuroscientist
DATE OF BIRTH January 10, 1944
PLACE OF BIRTH Chiesch