Hyperestrogenism

Classification according to ICD-10
E28.0	Hyperestrogenism
ICD-10 online (WHO version 2019)

The hyperestrogenism is a disease image obtained by an over-production of female sex hormones ( estrogens is caused). The disease occurs in both women and men and can have many different causes.

The disease can also occur in animals. For dogs, see Hyperestrogenism in the Dog .

Causes and forms

Depending on the underlying disorder, a distinction can be made between the following forms and diseases:

• Alcohol sickness
• Moles
• familial hyperestrogenism, ( hereditary disease ), synonyms aromatase excess syndrome ; AEXS; Familial hyperestrogenism; Prepubertal gynecomastia, hereditary
• feminine hyperestrogenism in hormone-active (ovarian) tumors
• hypergonadotropic hyperestrogenemia, (increased concentration of gonadotropins ), usually onset of menopause ( climacteric )
• Hyperthyroidism
• Cirrhosis of the liver
• Drug hyperestrogenism in estrogen overdosage, also zearalenone , a mycotoxin
• Ovarian hyperestrogenism with impaired function of the ovary with excess estrogen
• Suprarenal hyperestrogenism with increased hormone production in the adrenal cortex
• testicular hyperestrogenism with primary inadequate function of the testicle or androgen resistance

and other rarer diseases.

Clinical manifestations

In the male sex, feminization occurs in adults with a loss of libido and potency, in adolescents hypogenitalism , and before that there may be malformations of the secondary genital organs . In the female sex, endometrial changes, mukometra , prolonged menstruation or menstrual cramps can occur.

literature

• RV Lloyd: Endocrine Pathology :: Differential Diagnosis and Molecular Advances. 2010, Springer, p. 316. ISBN 978-1-4419-1068-4 .
• R. Chwalla: [Hyperestrogenism in the male and its effects]. In: Wiener medical Wochenschrift. Volume 110, August 1960, pp. 641-646, PMID 13693562 .

Individual evidence

1. ^ NA Prado-Oviedo, EJ Malloy, X. Deng, JL Brown: Hyperprolactinemia is not associated with hyperestrogenism in noncycling African elephants (Loxodonta africana). In: General and comparative endocrinology. Volume 189, August 2013, pp. 7-14, doi: 10.1016 / j.ygcen.2013.03.035 , PMID 23623777 .
2. ↑ T. Micheletti, JL Brown, SL Walker, ZS Cubas, PV Furtado, SB Putman, W. de Moraes, MJ de Oliveira, CA de Oliveira, N. Moreira: The use of altrenogest to avoid hyperestrogenism after eCG-hCG ovulation induction in southern tigrina (Leopardus guttulus). In: Theriogenology. Volume 84, Number 4, September 2015, pp. 575-582, doi: 10.1016 / j.theriogenology.2015.04.015 , PMID 26001599 .
3. ↑ Aromatase excess syndrome. In: Orphanet (Rare Disease Database).
4. ↑ Rosenfluh
5. ↑ L. Lajos, J. Gorcs, G. Illei, L. Kecskes, F. Mutschler, I. Glos: About climacteric herestrogenism. In: Journal of Obstetrics and Gynecology. Vol. 159, September 1962, pp. 308-328, PMID 13928147 .
6. ↑ HK Kley, W. Wiegelmann, E. Nieschlag, HL Krüskemper: Liver cirrhosis and hyperestrogenism. In: German Medical Weekly . Volume 101, Number 35, August 1976, pp. 1295-1298, doi: 10.1055 / s-0028-1104260 , PMID 782810 (review).
7. ↑ G. Buzási, J. Juhász, L. Fehér: [A case of polyostotic fibrous dysplasia (Albright syndrome) with gynecomastia and hyperestrogenism]. In: Endocrinology. Volume 52, Number 3, 1967, pp. 145-152, PMID 5589132 .
8. ↑ LJ Valenta, AN Elias: Male hypogonadism due to hyperestrogenism. In: The New England Journal of Medicine . Volume 314, Number 3, January 1986, p. 186, PMID 3941702 .
9. ^ Gesundheit.de

Web links

• Science Direct

This article is about a health issue. It is not used for self-diagnosis and does not replace a diagnosis by a doctor. Please note the information on health issues !