J. Andrew McCammon

James Andrew McCammon , called Andrew McCammon, (born February 8, 1947 in Lafayette , Indiana ) is an American chemist ( theoretical chemistry , biochemistry , pharmacology ). He is a professor at the University of California, San Diego (UCSD).

McCammon attended Pomona College with a bachelor's degree in 1969 and Harvard University , where he received his doctorate in physical chemistry in 1976 with John M. Deutch with the thesis Hydrodynamics of biopolymers . As a post-doctoral student he was with Martin Karplus at Harvard until 1978 , where he developed computer simulations for protein dynamics. In 1978 he became an Assistant Professor at the University of Houston , where he became MD Anderson Professor of Chemistry in 1981. In 1995 he became a professor at UCSD, where he is Joseph E. Mayer Professor of Theoretical Chemistry and Distinguished Professor of Pharmacology. From 1987 to 1994 he was director of the Institute of Molecular Design and from 1986 to 1994 he was adjunct professor at Baylor College. From 1995 he was a Senior Fellow at the San Diego Supercomputer Center.

Since 2000 he has been a scientist at the Howard Hughes Medical Institute .

McCammon is known for applying computational chemistry with supercomputers to biological questions, for which he received the Cray Research Information Technology Leadership Award and the Smithsonian Award for Breakthrough Computational Science in 1995. He used methods of computational chemistry in the search for new active ingredients. For this he received the George H. Hitchings Award in 1987. He developed methods to accurately predict properties such as molecular recognition and reaction rates. As author and co-author, he has produced around 800 scientific publications.

In pharmacology, he founded the drug research program of Agoural Pharmaceuticals (now La Jolla Laboratories from Pfizer Global Research), which developed the HIV- 1 protease inhibitor nelfinavir (Viracept) in the 1980s . His research also contributed to the development of Merck's protease inhibitor raltegravir (Isentress), which was approved in 2007.

With Stephen Harvey , he wrote a textbook on molecular mechanics and dynamics in biochemistry.

In 2011 he became a member of the National Academy of Sciences and in 2006 the American Academy of Arts and Sciences . He is a Fellow of the American Chemical Society (ACS), the Biophysical Society , the American Physical Society, and the American Association for the Advancement of Science . In 2008 he received the ACS Award for Computers in Chemical and Pharmaceutical Research from ACS and in 2016 the Joseph O. Hirschfelder Prize . In 1982 he received the Dreyfuß Teacher Scholar Award.

In 1980 he was a Sloan Research Fellow .

Fonts

• with Stephen Harvey: Dynamics of Proteins and Nucleic Acids, Cambridge University Press, 1987

Web links

• McCammon Group

Individual evidence

1. ↑ Birth and career data according to American Men and Women of Science Thomson Gale 2004
2. ↑ biographical data, publications and Academic pedigree of J. Andrew McCammon at academictree.org, accessed on 2 January of 2019.