Jonathan Weissman
Jonathan S. Weissman is an American biochemist, biophysicist, and cell biologist.
Weissman studied physics at Harvard University with a bachelor's degree in 1988 and received his PhD in biophysics in 1993 with Peter S. Kim at the Massachusetts Institute of Technology . At that time he investigated protein folding using the example of aprotinin (BPTI). From 1993 to 1996 he was a post-doctoral student with Arthur Horwich at Yale University , where he investigated the Chaperones GroEL.
He has been a researcher at the Howard Hughes Medical Institute since 2000 (from 2005 as an investigator ) and Professor of Cellular and Molecular Pharmacology at the University of California, San Francisco (UCSF). He is the director of the Innovative Genome Initiative at the Universities of Berkeley and San Francisco.
He is on Amgen's Scientific Advisory Board .
In 2008 he received the Sackler Prize in Biophysics and in 2015 he gave the Keith R. Porter Lecture of the American Society of Cell Biology . In 2015 he received the first NAS Award for Scientific Discovery for the development of Ribosome Profiling , a powerful technique that enables genome-wide analysis of protein synthesis in living cells with high resolution. It is based on sequencing the messenger RNA in the cells, which produces a snapshot of the cell's gene transcription. Among other things, they researched the mechanisms of cell growth and cell differentiation and gene interaction maps. In addition, together with Stanley Qi, Adam Arkin, Jennifer Doudna and Wendell Lim (both from HHMI) he developed the CRISPRi technology for the targeted regulation of gene expression. It is based on the catalytically inactive CRISPR- linked protein dCas9.
He is also concerned with the control of protein folding and defects in protein folding and their role in diseases and in normal cells, where protein folding mostly takes place in the endoplasmic reticulum (ER). Weissman investigates the special conditions in the ER of the cell for protein folding.
Weissman has been a member of the National Academy of Sciences since 2009 .
Fonts (selection)
- with Nicholas T. Ingolia, Liana F. Lareau: Ribosome Profiling of Mouse Embryonic Stem Cells Reveals the Complexity and Dynamics of Mammalian Proteomes , Cell, Volume 147, 2011, pp. 789-802. PMID 2205604
Web links
Individual evidence
| personal data | |
|---|---|
| SURNAME | Weissman, Jonathan |
| ALTERNATIVE NAMES | Weissman, Jonathan S. |
| BRIEF DESCRIPTION | American biochemist |
| DATE OF BIRTH | 20th century |