Jennifer Doudna

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Jennifer Doudna (2016)

Jennifer A. Doudna Cate (born February 19, 1964 in Washington, DC ) is an American biochemist and molecular biologist at the University of California, Berkeley . With pioneering work, she was able to contribute to the elucidation of complex structures of catalytically active RNA (so-called ribozymes ).

Life

Doudna grew up with Hilo in Hawaii . She earned a bachelor's degree from Sharon M. Panasenko at Pomona College in 1985 and a PhD from Jack W. Szostak at Harvard University in 1989 . As a postdoctoral fellow , she worked with Szostak and Thomas R. Cech at the University of Colorado . In 1994 she received her first professorship at Yale University (Assistant Professor) and rose to a full professorship by 2000. In 2000/2001 she was visiting professor at Harvard University before moving to the University of California, Berkeley in 2003.

Doudna has also been researching for the Howard Hughes Medical Institute since 1997 and has also worked for the Lawrence Berkeley National Laboratory since 2003 . Her husband, Jamie H. Doudna Cate (* 1968), was one of her first students and is now (as of 2019) also a professor at the University of California, Berkeley.

According to Google Scholar , Doudna (as of April 2019) has an h-index of 110. Since 2015, Thomson Reuters has counted her among the favorites for a Nobel Prize in chemistry due to the high number of her citations .

Act

Doudna carried out innovative research that led to a method that enables the crystallization of large RNA molecules. It determined the crystal structure of catalytically active RNA molecules ( ribozymes ) and of the RNA molecule that forms the ribonucleoprotein core of the signal recognition particle . She deciphered the structural properties of these molecules and thus enabled a deeper understanding of the function of RNA in catalysis and protein biosynthesis . In 2012 she and Emmanuelle Charpentier published a fundamental paper on the CRISPR / Cas method with the demonstration of the use of Cas9 to make sections in any DNA sequence. In addition, she was involved in the development of CRISPRi .

Recent work (as of 2014) are concerned with the role of mRNA structure in microRNA mediated gene regulation , with the internal ribosomal entry site ( internal ribosomal entry site ) , with the structural and biochemical characterization of CRISPR -mediated bacterial immune system , with the structure and functioning of the signal recognition particle and with the RNA recognition by Dicer enzymes.

Awards (selection)

Web links

Commons : Jennifer Doudna  - collection of images, videos and audio files

literature

Individual evidence

  1. ↑ Kara Rogers: Jennifer Doudna in the Encyclopaedia Britannica (britannica.com); accessed on December 22, 2017.
  2. ^ The Doudna Lab - People at the Doudna Lab (doudnalab.org); accessed on April 20, 2019
  3. ↑ Jamie HD Cate and Jamie HD Cate at the University of California, Berkeley (berkeley.edu); accessed on April 20, 2019
  4. ↑ Jennifer Doudna. In: scholar.google.de. Google Scholar , accessed April 20, 2019 .
  5. ↑ Announcing the 2015 Citation Laureates , at Thomson Reuters.
  6. ↑ a b Alan T. Waterman Award Recipients (2000) at the National Science Foundation (nsf.org); accessed on August 21, 2014
  7. ↑ M. Jinek, K. Chylinski, I. Fonfara, M. Hauer, JA Doudna, E. Charpentier: A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity, Science, Volume 337, 2012, pp. 816-821 , PMID 22745249
  8. ^ William O. Baker Award for Initiatives in Research at the National Academy of Sciences (nasonline.org); accessed on January 13, 2016
  9. ^ Eli Lilly Award in Biological Chemistry , laureate (PDF; 45 kB) at the Biochemistry Section of the American Chemical Society (divbiolchem.org); accessed on August 21, 2014
  10. ↑ Jennifer A. Doudna at the National Academy of Sciences (nasonline.org); accessed on August 21, 2014
  11. ↑ Book of Members 1780 – present, Chapter D. (PDF; 575 kB) In: American Academy of Arts and Sciences (amacad.org). Retrieved September 13, 2019 .
  12. ↑ Jennifer Doudna, Ph.D., and Emmanuelle Charpentier, Ph.D., Win 2014 Dr. Paul Janssen Award for Biomedical Research at pauljanssenaward.com; accessed on August 21, 2014
  13. ^ Gabbay Award - Current Winners at Brandeis University (brandeis.edu); accessed on August 21, 2014
  14. ↑ Paul Ehrlich and Ludwig Darmstaedter Prize Winners and Young Talent Prize Winners 2016. In: uni-frankfurt.de. March 14, 2016, accessed December 7, 2016 .
  15. ↑ Tang Prize 2016
  16. ↑ College of Science Communications, Texas A&M: UC Berkeley Prof and Howard Hughes Medical Institute Investigator Jennifer Doudna to Receive 2017 Cotton Medal. In: today.tamu.edu. March 31, 2017, accessed September 13, 2019 .
  17. ↑ Harvey Prize 2018
personal data
SURNAME Doudna, Jennifer
ALTERNATIVE NAMES Doudna, Jennifer A .; Doudna Cate, Jennifer A.
BRIEF DESCRIPTION American biochemist and molecular biologist
DATE OF BIRTH 19th February 1964
PLACE OF BIRTH Washington, DC