Collagen hydrolyzate

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Collagen hydrolyzate is obtained from collagen and is legally a food. A special form of collagen hydrolyzate is often used in dietary supplements . Collagen is an extracellular structural protein , i.e. a protein that is responsible for the firmness and flexibility of the connective tissue . It makes up 25% to 30% of the protein in animals and humans.

Collagen is insoluble under physiological conditions, but it can be hydrolyzed by heat, bases, or weak acids . If collagen hydrolyzed in this way is cleaned, concentrated, sterilized , dried and ground, it becomes gelatin . Gelatin can bind significant amounts of water, which is why it is often used in food and pharmaceuticals .

In contrast to gelatin, collagen hydrolyzate is enzymatically hydrolyzed collagens that are soluble in water. However, they are readily dispersible and emulsion-stabilizing, which is why they are used in hair cosmetics to improve dry and wet combability or hair shine or to improve the absorption of colorants on hair and woolen textiles. Furthermore, collagen hydrolyzate is used in cosmetics in topical skin care creams to keep the moisture in the skin longer. The greatest use of collagen hydrolyzate is in products that are high in protein. Since, unlike other proteins, there is practically no risk of allergens and clear, non-bitter drinks can be made with them, they are widely used in protein powders, drinks or bars. They are used in the food sector, in the meat industry as well as in the confectionery and beverage industry, and in pharmacy, above all, as tabletting agents, coating agents and fillers. Collagen hydrolyzate is also used in dietary supplements to ensure an improved supply of nutrients to the joints with easily usable collagen peptides and thus to enable the reconstruction of damaged cartilage tissue .

effect

Suppliers of dietary supplements use collagen hydrolysates, which contain collagen peptides which, as essential nutrients , should enable the build-up, maintenance and regeneration of stressed or damaged cartilage tissue after oral intake. These special collagen hydrolysates stimulate the body's cartilage cells to produce more cartilage tissue . Collagen hydrolyzates are used to prevent and treat cartilage wear in the joints. In affected patients, the intake of collagen hydrolyzate should lead to a reduction in pain and an improvement in joint mobility. Another area of ​​application for collagen hydrolysates with short-chain collagen peptides is the stimulation of skin regeneration with improvement in skin health. The drinking collagens are also administered as nutritional supplements and, unlike purely superficial and short-term cosmetics, can also reach the deeper layers that are crucial for the regeneration of the skin due to their high bioavailability.

Studies

For over two decades, scientists have been researching the effects of collagen hydrolyzate on articular cartilage. But it wasn't until 2011 that McAlindon et al. in a clinically controlled gold standard study using objective parameters such as MRI (Magnetic Resonance Imaging using the newly developed dGEMRIC technology) to prove that a collagen hydrolyzate with short-chain collagen peptides can not only inhibit the degeneration of the articular cartilage, but also stimulate its regeneration.

Initial studies by the University of Kiel have indicated that the administration of collagen hydrolyzate can promote the formation of new cartilage and show that the radioactively labeled short-chain collagen peptides actually accumulate in the joints and can stimulate cartilage formation there. For the first time, both the very good bioavailability and the bioactivity of certain collagen hydrolysates with short-chain collagen peptides could be demonstrated. The long-term study by McAlindon then produced clear clinical proof of effectiveness in 2011. Hunter and Henrotin both independently come to the conclusion in 2011 that collagen hydrolyzate is a promising nutrient for maintaining and restoring joint structure and function, thus joining the first cautiously positive assessment by Moskowitz in 2000. Several clinical studies consistently showed a strong effect on skin regeneration, skin moisture and skin elasticity of collagen hydrolyzate with short-chain oligopeptides from collagen. The depth of wrinkles could be significantly and sustainably reduced. The complexion was visibly and sustainably improved. The age-related decline in the synthesis of collagen and other components of the extracellular matrix of the skin could be positively influenced. These mechanisms are also discussed as the basis for the positive effects of collagen hydrolyzate on people with cellulite. For example, a double-blind, placebo-controlled clinical study on 105 women showed that the daily intake of 2.5 g of collagen hydrolyzate over a period of 6 months significantly improves skin density and texture and reduces the dents that are typical of cellulite.

criticism

The European Food Safety Authority (EFSA) also recognizes the results of the McAlindon study from 2011, but does not issue a health claim for collagen hydrolyzate in food supplements, since this study was carried out on osteoarthritis patients and not on healthy volunteers. In the context of the Klartext Dietary Supplement project, the consumer advice centers note: "There is not even enough reliable scientific evidence for the general benefit of collagen hydrolyzate in people with knee osteoarthritis. Due to the inadequate state of studies, the international osteoarthritis society OARSI (Osteoarthritis Research Society International) does not include collagen hydrolyzate in their current guidelines for the treatment of knee osteoarthritis. "

See also

Individual evidence

  1. ↑ Schlippe et al. (2015): Influence of the oral intake of collagen peptides on relevant parameters of skin aging: skin moisture, skin elasticity and skin roughness. In: Current Dermatology , 41: 529-534.
  2. ↑ a b Proksch et al. (2014) Skin Pharmacol Physiol; 27: 47-55
  3. ↑ a b c McAlindon TE et al. (2011): Change in knee osteoarthritis cartilage detected by delayed gadolinium enhanced magnetic resonance imaging following treatment with collagen hydrolysate: a pilot randomized controlled trial . In: Osteoarthritis Cartilage 19 (4): 399-405.
  4. ↑ Oesser S. et al. (1999): Oral administration of 14 C labeled gelatin hydrolysate leads to accumulation of radioactivity in cartilage of mice (C57 / BL) . In: J Nutr 129: 1891-1895.
  5. ↑ Oesser S. et al. (2003): Stimulation of type II collagen biosynthesis and secretion in bovine chondrocytes cultured with degraded collagen. Cell Tiss Res 311: 393-399.
  6. ↑ a b Moskowitz RW (2000): Role of collagen hydrolysate in bone and joint disease . In: Semin Arthritis Rheum 30: 87-99.
  7. ↑ a b c Hunter D. (2011): Pharmacologic therapy for osteoarthritis - the era of disease modification . In: Nat Rev Rheumatol 54: 47-49.
  8. ↑ a b Henrotin Y. et al. (2011): Nutraceuticals: do they represent a new era in the management of osteoarthritis? - a narrative review from the lessons taken with five products . In: Osteoarthritis Cartilage 19 (1): 1-21.
  9. ↑ Proksch, E., Schunck, M., Zague, V., Segger, D., Degwert, Oesser, S. (2014): Oral Intake of Specific Bioactive Collagen Peptides Reduces Skin Wrinkles and Increases Dermal Matrix Synthesis ; In: Skin Pharmacol Physiol 2014; 27: 113-119
  10. ↑ Schunck, M., Zague, V., Oesser, S., Proksch, E. (2015): Dietary Supplementation with Specific Collagen Peptides Has a Body Mass Index-Dependent Beneficial Effect on Cellulite Morphology . In: J Med Food 00 (0) 2015 , 1-9. doi : 10.1089 / jmf.2015.0022 .
  11. ↑ EFSA Panel on Dietetic Products, Nutrition and Allergies (2011): Scientific opinion on the substantiation of a health claim related to collagen hydrolysate and maintenance of joints pursuant to Article 13 (5) of Regulation (EC) No 1924/2006. EFSA Journal 9 (7): 2291. doi : 10.2903 / j.efsa.2011.2291 .
  12. ↑ Collagen hydrolyzate for knee problems klartext-nahrungsergaenzung.de accessed on January 17, 2019