Levodropropizine
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Non-proprietary name | Levodropropizine | ||||||||||||||||||
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Molecular formula | C 13 H 20 N 2 O 2 | ||||||||||||||||||
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Molar mass | 236.31 g · mol -1 | ||||||||||||||||||
Physical state |
firmly |
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Melting point |
102-104 ° C |
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As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
Levodropropizin is a drug from the group of antitussives (cough suppressants). It is used for irritable and convulsive coughs and irritations of the upper respiratory tract . The active ingredient must not be used in the case of impaired liver or kidney function, severe cardiovascular problems and children under 2 years of age. There is no experience on use during pregnancy or breastfeeding. At high doses, there may be a short-term drop in blood pressure and a racing heart . Occasionally, tiredness, nausea, vomiting, mild diarrhea , drowsiness and headache may occur, and rarely allergic reactions .
Levodropropizin contains a stereocenter in the propanediol residue ; it is used as the ( S ) enantiomer ( eutomer of the drug dropropizine ).
Manufacturing
Levodropropizine can be produced from dropropizine by resolution with lipases from Pseudomonas cepacia .
See also
The structurally related drug dropropizine is a racemate [1: 1 mixture of ( S ) -3- (4-phenylpiperazin-1-yl) propane-1,2-diol (levodropropizine) and ( R ) -3- (4- Phenylpiperazin-1-yl) propane-1,2-diol] and is also used as a cough suppressant.
Individual evidence
- ^ R. Giani, E. Marinone, G. Melillo, M. Borsa, GC Tonon: Synthesis and Pharmacological Screening of New Phenylpiperazinepropane Derivatives and Their Enantiomers . In: Medicines Research . tape 38 , no. 8 , 1988, pp. 1139-1141 .
- ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
- ↑ Manikrao M. Salunkhe and Ranjeet V. Nair: Novel route for the resolution of both enantiomers of dropropizine by using oxime esters and supported lipases of Pseudomonas cepacia , Enzyme and Microbial Technology 28 ( 2001 ) 333-338, PMID 11240188 .
- ↑ External identifiers of or database links to (+) - dropropizin : CAS number: 99291-24-4, PubChem : 688451 , ChemSpider : 599912 , Wikidata : Q27278167 .