Manfred Schlosser

Manfred Schlosser (born June 12, 1934 in Ludwigshafen am Rhein , † after June 26, 2013 ) was a German chemist.

life and work

Schlosser studied from 1952 chemistry and medicine at the University of Heidelberg , where in 1957 he the academic degree of diploma gained -Chemikers and 1960, when Georg Wittig Dr. rer. nat. received his doctorate . After further studies and a year of research (1962/63) at the Brussels research institute European Research Associates , he completed his habilitation in 1966 in Heidelberg. In 1967 he was employed as a senior physician at the German Cancer Research Center in Heidelberg and in 1972 professor at the University of Lausanne . In 2001 he moved to the ETH Lausanne , where he retired in 2004 . Guest professorships have taken him to Italy (Perugia, Florence), Germany (Berlin), Hungary (Budapest), Japan (Kyoto) and the USA (San Jose).

Schlosser worked on the interface between organic chemistry and chemical synthesis . He developed the stereoselective olefination (Schlosser variant of the Wittig reaction ), the copper-catalyzed alkylation of organomagnesium compounds (Fouquet-Schlosser coupling) and the Schlosser base , a superbase . He also developed new cytostatics and researched organohalogen compounds.

One of his hobbies was hiking. At the end of June 2013 he did not return from a hike in the Vaudois Alps and has been missing since then.

Publications (selection)

Schlosser published more than 400 scientific papers.

• Carbonyl olefinations with phosphine-alkylenes . Dissertation, Heidelberg 1960.
• Mechanism of the dehydrochlorination of vinyl chlorides with organolithium reagents and stereochemistry of carbonyl olefination with phosphorus ylides . Habilitation thesis. Heidelberg 1966.
• Structure and reactivity of polar organometals. An introduction to the chemistry of organic alkali and alkaline earth metal compounds (= organic chemistry in individual representations. Volume 14). Springer, Berlin et al. 1973, ISBN 3-540-05719-6 .
• Chem Art universal 3.5 chemistry stencil = Chem Art universal 3.5 chemistry stencil . Verlag Chemie, Weinheim et al. 1981, ISBN 3-527-10081-4 .
• as editor: Organometallics in Synthesis. A manual . Wiley, Chichester et al. 1994, ISBN 0-471-93637-5 .

literature

• Kürschner's German Scholars Calendar 2014. 26th edition. Volume 3, Walter de Gruyter, Berlin / Boston 2014, ISBN 978-3-11-030256-1 , p. 3207.
• Manfred Schlosser: Parameterization of substituents - the influence of fluorine and other heteroatoms on OH, NH and CH acidities. In: Angewandte Chemie. Volume 110, No. 11, 1999, pp. 1538-1556, doi : 10.1002 / (SICI) 1521-3757 (19980605) 110: 11 <1538 :: AID-ANGE1538> 3.0.CO; 2-B . (on p. 1540 there is a short curriculum vitae with a picture)
• Frédéric Leroux: Manfred Schlosser (1934–2013). In: Angewandte Chemie . Volume 125, No. 48, November 25, 2013, p. 12711, doi: 10.1002 / anie.201308231 .

Web links

• Literature by and about Manfred Schlosser in the catalog of the German National Library
• Manfred Schlosser on epfl.ch ( Memento from February 13, 2003 in the Internet Archive ) (English)

Individual evidence

1. ↑ Manfred Schlosser, KF Christmann: Trans-selective olefin syntheses. In: Angewandte Chemie . Volume 78, No. 1, January 7, 1966, p. 115, doi: 10.1002 / ange.19660780118 .
2. ↑ Gerd Fouquet , Manfred Schlosser: Better CC linkages through controlled copper catalysis. In: Angewandte Chemie. Volume 86, No. 1, 1974, pp. 50-51, doi: 10.1002 / anie.19740860113 .
3. ↑ Manfred Schlosser: For the activation of organolithium reagents. In: Journal of Organometallic Chemistry . Volume 8, No. 1, April 1967, pp. 9-16, doi: 10.1016 / S0022-328X (00) 84698-7 ; also called Lochmann-Schlosser-Base after: L. Lochmann, J. Pospíšil, D. Lím: On the Interaction of Organolithium Compounds with Sodium and Potassium Alkoxides. A New Method for the Synthesis of Organosodium and Organopotassium Compounds. In: Tetrahedron Letters . Volume 7, No. 2, 1966, pp. 257-262, doi: 10.1016 / S0040-4039 (00) 70224-3 .