Mark J. Smyth

Mark J. Smyth (born April 4, 1963 in Hobart , Tasmania ) is an Australian immunologist at the QIMR Berghofer Medical Research Institute in Brisbane, Australia .

Smyth received a BA from the University of Melbourne in 1984 and a Ph.D. in 1988. in pathology . As a postdoc and research fellow , he worked at the Frederick Cancer Research and Development Center of the National Cancer Institute in Frederick , Maryland , and at the Austin Research Institute in Heidelberg , Victoria . From 1994 he took over his own research groups and, together with Joseph Trapani, became head of the program for cancer immunology at the Peter MacCallum Cancer Center in Melbourne in 2000 . From 1998 to 2000 he was a professor at Victoria University of Technology . Since 2013 he has been at the QIMR Berghofer Medical Research Institute in Brisbane.

Mark Smyth made important contributions to the elucidation of the role of the innate and adaptive immune systems in the control of cancer . He made important discoveries about the expression and regulation of perforin , was able to clone novel granzymes and outline the killing effect of granules on cancer cells and to elucidate the natural anti-tumor effect of Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL). He also showed that the course of cancer can be shaped by the selection of cancer cells that evade the immune system (immunoediting) , paving the way for the development of immune checkpoint inhibitors . Other important contributions deal with the function of NK cells and NKT cells or CD73 and CD96 as target molecules of cancer immunotherapy .

Smyth is the most cited immunologist in Australia. It has (as of September 2018) an h-index of 140.

Awards (selection)

2002 William B. Coley Award
2004 member of the Faculty of 1000
2007 Charles Rodolphe Brupbacher Prize for Cancer Research
2017 member of the Australian Academy of Science

Web links

Professor Mark Smyth at the QIMR Berghofer Medical Research Institute
Laudation (including curriculum vitae, status 2007) at the Charles Rodolphe Brupbacher Foundation

Individual evidence

^ Mark J. Smyth - Google Scholar Citations. In: scholar.google.de. Retrieved September 5, 2018 .
^ William B. Coley Award. In: cancerresearch.org. Retrieved September 5, 2018 .
↑ Mark Smyth - F1000Prime. In: f1000.com. Retrieved September 6, 2018 .
^ Brupbacher Prize. In: brupbacher-foundation.org. Retrieved September 21, 2019 .
^ Professor Mark Smyth - Australian Academy of Science. In: science.org.au. Retrieved September 5, 2018 .
↑ QIMR Berghofer immunologist elected AAS Fellow. In: qimrberghofer.edu.au. May 22, 2017, accessed September 5, 2018 .

personal data
SURNAME	Smyth, Mark J.
ALTERNATIVE NAMES	Smyth, Mark
BRIEF DESCRIPTION	Australian immunologist
DATE OF BIRTH	April 4th 1963
PLACE OF BIRTH	Hobart , Tasmania

[1] Mark J. Smyth - Google Scholar Citations. In: scholar.google.de. Retrieved September 5, 2018 .

[2] William B. Coley Award. In: cancerresearch.org. Retrieved September 5, 2018 .

[3] Mark Smyth - F1000Prime. In: f1000.com. Retrieved September 6, 2018 .

[4] Brupbacher Prize. In: brupbacher-foundation.org. Retrieved September 21, 2019 .

[5] Professor Mark Smyth - Australian Academy of Science. In: science.org.au. Retrieved September 5, 2018 .

[6] QIMR Berghofer immunologist elected AAS Fellow. In: qimrberghofer.edu.au. May 22, 2017, accessed September 5, 2018 .