Mark Ptashne
Mark Steven Ptashne (born June 5, 1940 in Chicago ) is an American molecular biologist and professor at the Memorial Sloan-Kettering Cancer Center .
Life
Ptashne earned a bachelor's degree in chemistry from Reed College in Portland , Oregon in 1961 and a Ph.D. in molecular biology from Harvard University in Cambridge , Massachusetts . In 1971 he received a professorship there in molecular biology and in 1997 a professorship at the Memorial Sloan-Kettering Cancer Center , New York City .
Ptashne is also a passionate violinist , owner of a Stradivarius violin and has made CD recordings with this instrument.
Act
Ptashne carried out fundamental work on the isolation of repressors , which play an important role in the regulation of cellular processes. He succeeded in elucidating the interaction between repressors and other proteins (e.g. Cro ), which in turn interact with the DNA . He was able to describe the three-dimensional structure of the repressor and interacting DNA. While first work was carried out on the bacteriophage Lambda and described the regulation between the lysogenic cycle and the lytic cycle , Ptashne was later able to describe similar processes in yeasts and higher organisms. Due to his work, the yeast protein GAL4 is one of the best-studied transcription factors . The discovery that transcription factors usually consist of separable domains that mediate DNA binding or the interaction with coactivators and corepressors was the prerequisite for many important molecular biological techniques, such as the yeast two-hybrid system .
Awards (selection)
- 1973 Guggenheim scholarship
- 1975 Eli Lilly Award in Biological Chemistry
- 1977 membership of the American Academy of Arts and Sciences
- 1977 Charles-Léopold Mayer Prize
- 1979 Member of the National Academy of Sciences
- 1979 National Academy of Sciences Award in Molecular Biology
- 1985 Louisa Gross Horwitz Prize
- 1985 Gairdner Foundation International Award
- 1990 Alfred P. Sloan, Jr. Prize
- 1997 Massry Prize
- 1997 Albert Lasker Award for Basic Medical Research
literature
- Who's Who in America. 66th Edition, Volume 2: M – Z. Marquis Who's Who, Berkeley Heights 2011, ISBN 978-0-8379-7032-5 (Volume 2), ISBN 978-0-8379-7035-6 (Complete Works ), ISSN 0083-9396 , p. 3588
Web links
- CV (PDF; 146 kB) at mskcc.org; accessed on January 23, 2016
Individual evidence
- ↑ BookRags.com: Mark Steven Ptashne , accessed November 13, 2010
- ↑ markptashne.com ( memento of January 2, 2014 in the Internet Archive ), accessed on November 13, 2010
- ^ A b 1997 Albert Lasker Basic Medical Research Award: Lambda repressor and gene regulation at laskerfoundation.org; accessed on April 30, 2019.
- ↑ L. Keegan, G. Gill, M. Ptashne: Separation of DNA binding from the transcription-activating function of a eukaryotic regulatory protein . In: Science . 231, February 14, 1086, pp. 699-704. doi : 10.1126 / science.3080805 . PMID 3080805 .
- ↑ Book of Members 1780 – present, Chapter P. (PDF; 649 kB) In: American Academy of Arts and Sciences (amacad.org). Retrieved April 30, 2019 .
- ^ The Louisa Gross Horwitz Prize for Biology Or Biochemistry at columbia.edu; Retrieved November 12, 2010
- ^ Mark Ptashne PhD at the Gairdner Foundation (gairdner.org); Retrieved December 8, 2012
- ↑ Massry Prize Winners (1996 – Present) at usc.edu; accessed on April 30, 2019.
| personal data | |
|---|---|
| SURNAME | Ptashne, Mark |
| ALTERNATIVE NAMES | Ptashne, Mark Steven; Ptashne, Mark S. |
| BRIEF DESCRIPTION | American molecular biologist and professor at Memorial Sloan-Kettering Cancer Center |
| DATE OF BIRTH | June 5, 1940 |
| PLACE OF BIRTH | Chicago |