Methacholine

Structural formula
	Counterion (mostly chloride) not shown
General
Non-proprietary name	Methacholine chloride
other names	Acetylmethylcholine; 2-acetyloxypropyl-trimethyl-azanium ( IUPAC );
Molecular formula	C 8 H 18 NO 2 +
External identifiers / databases
PubChem	1993
ChemSpider	1916
DrugBank	DB06709
Wikidata	Q413188
Drug information
ATC code	V04 CL01
Drug class	Direct parasympathomimetics
properties
Molar mass	195.69 g mol −1 (methacholine chloride)
Physical state	solid (methacholine chloride)
Melting point	172-173 ° C (methacholine chloride)
solubility	easily soluble in water, ethanol and chloroform (methacholine chloride)
safety instructions
	Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances Caution
H and P phrases	H: 302-315-319-335
	P: 261-305 + 351 + 338
Toxicological data	44 mg kg −1 ( LD 50 , mouse , ip )
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Methacholine is a drug from the group of muscarinic receptor agonists. Methacholine is used in a lung provocation test called the methacholine test , and thus plays a role in the diagnosis of bronchial asthma .

→ Main article: Methacholine test

Pharmacological properties

Methacholine is broken down more slowly by cholinesterases than acetylcholine .

Provocholine (USA, CDN), Provokit (D), Lindo (D), Nabit (D)

^ ^A ^b ^c The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals, 14th Edition (Merck & Co., Inc.), Whitehouse Station, NJ, USA, 2006; P. 1026, ISBN 978-0-911910-00-1 .
↑ ^a ^b Data sheet Acetyl-β-methylcholine chloride from Sigma-Aldrich , accessed on April 10, 2011 ( PDF ).
^ Entry on methacholine in the ChemIDplus database of the United States National Library of Medicine (NLM) .