Methyl anisoles

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Methyl anisoles
Surname 2-methyl anisole 3-methyl anisole 4-methyl anisole
other names o -Methylanisol,
2-methoxytoluene,
o -Kresylmethylether 		m -Methylanisol,
3-methoxytoluene,
m -Kresylmethylether 		p -Methylanisol,
4-methoxytoluene,
p -Kresylmethylether
Structural formula Structure of 2-methyl anisole Structure of 3-methyl anisole Structure of 4-methyl anisole
CAS number 578-58-5 100-84-5 104-93-8
ECHA InfoCard 100.008.571 100.002.631 100.002.958
PubChem 33637 7530 7731
Molecular formula C 8 H 10 O
Molar mass 122.17 g mol −1
Physical state liquid
Brief description colorless liquid yellowish liquid yellowish liquid
Melting point −34.1 ° C - −50 ° C
boiling point 170-172 ° C 175-180 ° C 174-177 ° C
GHS
labeling
02 - Highly / extremely flammable
Caution
02 - Highly / extremely flammable
Caution
02 - Highly / extremely flammable 07 - Warning
Caution
H and P phrases 226 226 226-302-315
no EUH phrases no EUH phrases no EUH phrases
no P-phrases no P-phrases no P-phrases

The methyl anisoles (also methoxytoluenes or cresyl methyl ether ) form a group of substances in chemistry that is derived from both anisole and toluene . The structure consists of a benzene ring with attached methoxy  (–OCH 3 ) and methyl groups  (–CH 3 ) as substituents . Their different arrangement results in three constitutional isomers with the empirical formula C 8 H 10 O.

properties

The methyl anisoles are colorless to yellowish liquids that boil in the range from 170 to 180 ° C.

presentation

Methyl anisoles can be prepared from the cresols by etherification with dimethyl sulfate .

Risk assessment

In 2012, 4-methyl anisole was included in the EU's ongoing action plan ( CoRAP ) in accordance with Regulation (EC) No. 1907/2006 (REACH) as part of substance evaluation . The effects of the substance on human health and the environment are re-evaluated and, if necessary, follow-up measures are initiated. Ingestion of 4-methyl anisole was caused by concerns about its classification as a CMR substance, consumer use , high risk characterization ratio (RCR) and widespread use. The re-evaluation took place from 2012 and was carried out by Ireland . A final report was then published.

Web links

Commons : Methyl Anisole  - Collection of pictures, videos, and audio files

Individual evidence

  1. ↑ a b c Entry on 2-methyl anisole in the GESTIS substance database of the IFA , accessed on March 13, 2017(JavaScript required) .
  2. ↑ a b c Entry on 3-methyl anisole in the GESTIS substance database of the IFA , accessed on March 13, 2017(JavaScript required) .
  3. ↑ a b c Entry on 4-methyl anisole in the GESTIS substance database of the IFA , accessed on March 13, 2017(JavaScript required) .
  4. ^ Association of authors: Organikum , 19th edition, Johann Ambrosius Barth, Leipzig · Berlin · Heidelberg 1993, ISBN 3-335-00343-8 , p. 209.
  5. ↑ European Chemicals Agency (ECHA): Substance Evaluation Conclusion and Evaluation Report .
  6. ↑ Community rolling action plan ( CoRAP ) of the European Chemicals Agency (ECHA): 4-methylanisole , accessed on May 20, 2019.