Michael Anthony Gimbrone

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Michael Anthony Gimbrone (born November 16, 1943 in Buffalo (New York) ) is an American biologist and physician who studies the biology and pathology of blood vessel walls ( angiology ).

Gimbrone studied zoology from Cornell University with a bachelor's degree summa cum laude in 1965, and medicine from Harvard Medical School , where he made his M.D. degree in 1970. After completing his internship at Massachusetts General Hospital , he went into research at Children's Hospital Medical Center in Boston and then at the National Cancer Institute in Bethesda . He then began a residency as a pathologist at Bent Brigham Hospital in Boston, where he founded a vascular pathology research laboratory in 1976 and became professor of pathology in 1985. He is Elsie T. Friedman Professor of Pathology at Harvard Medical School and Director of the Center of Excellence in Vascular Biology and Director of Pathology at Brigham and Women's Hospital in Boston.

Grimbone researched diseases of the blood vessel walls such as arteriosclerosis , thrombosis and inflammation, pioneering the development of in vitro research methods. In his laboratory, he examined the interaction of endothelial cells with messenger substances ( cytokines ) and cells of the immune system and, together with his group, discovered in 1987 ELAM-1 molecules (endothelial cell adhesion molecules), which are formed by endothelial cells after stimulation by cytokines and a Play a role in the accumulation of white blood cells ( neutrophils ) on the vessel wall, especially in inflammation. They were also cloned at Gimbrone's laboratory in 1989. In his laboratory, Gimbrone discovered other adhesion molecules such as selectins and VCAM-1, which play a role in arteriosclerosis.

Gimbrone received the American Heart Association's Basic Research Prize in 1993 and the Pasarow Award in 1996 . In 1999 he received the J. Allyn Taylor International Prize in Medicine with Judah Folkman and in 2006 the King Faisal Prize in Medicine. In 1997 he became a member of the National Academy of Sciences and in 1999 of the American Academy of Arts and Sciences . He was President of the American Society for Investigative Pathology (FASEB), from which he received the Lambert / Parke Davis Award in Experimental Pathology.

Web links

Individual evidence

  1. ↑ With Michael P. Bevilacqua, Jordan S. Pober, Donna L. Mendrick and Ramzi S. Cotran: Identification of an inducible endothelial-leukocyte adhesion molecule. In: Proceedings of the National Academy of Sciences of the United States of America . Vol. 84, No. 24, 1987, pp. 9238-9242, PMC 299728 (free full text); with Michael P. Bevilacqua, Siegfried Stengelin and Brian Seed: Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins. In: Science . Vol. 243, No. 4895, 1989, pp. 1160-1165, doi : 10.1126 / science.2466335 .
  2. ↑ projects from the laboratory of Gimbrone
personal data
SURNAME Gimbrone, Michael Anthony
ALTERNATIVE NAMES Gimbrone, Michael A.
BRIEF DESCRIPTION American medic
DATE OF BIRTH November 16, 1943
PLACE OF BIRTH Buffalo (New York)