Michael Elowitz

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Michael B. Elowitz (born May 9, 1970 ) is an American physicist and systems biologist . He is a professor at Caltech and is considered a pioneer in synthetic biology .

Life

Elowitz grew up in Los Angeles , received his bachelor's degree in physics from the University of California at Berkeley in 1992 and his PhD in physics from Princeton University in 1999 . He was a post-graduate student at Rockefeller University . In 2003 he became an Assistant Professor of Biology and Applied Physics at Caltech. He is also a researcher at the Howard Hughes Medical Institute .

He investigates the interaction of genes theoretically and in in vivo studies of artificial genetic circuits. Experiments with Stanislas Leibler ( Represillator , published 2000 in Nature) on an artificial biological oscillator built into E. coli bacteria have shown that even with simple negative feedback loops in gene regulation, complex behavior can arise (evident from the production of a phosphor). The experiment was a key one in synthetic biology. Elowitz also showed with Eric Siggia and others that internal and external noise plays a large role in gene regulation (published in Science 2002).

He became a MacArthur Fellow in 2007 . In 2008 he received a Presidential Early Career Award in Science and Technology and in 2006 he was a Packard Fellow . In 2002 he received a Career Award from the Burroughs Wellcome Fund . In 2011 he was awarded the HFSP Nakasone Award and in 2019 the Sackler Prize . In 2015 Elowitz was elected to the American Academy of Arts and Sciences and in 2016 to the American Association for the Advancement of Science . He has been an associate member of the European Molecular Biology Organization since 2018 .

Fonts

  • with WA Lim: Build life to understand it , Nature, 468, 2010, 889-890
  • with GM Süel, RP Kulkarni, J. Dworkin, J. Garcia-Ojalvo: Tunability and noise dependence in differentiation dynamics , Science, 315, 2007, pp. 1716-1719.
  • Süel, Garcia-Ojalvo, L. Liberman: An excitable gene regulatory circuit induces transient cellular differentiation , Nature, 440, 2006, pp. 545-550.
  • with D. Sprinzak D: Reconstruction of genetic circuits , Nature, 438, 2005, pp. 443-448.
  • with N. Rosenfeld, JW Young, U. Alon, PS Swain: Gene regulation at the single-cell level , Science, 307, 2005, pp. 1962-1965
  • with AJ Levin, ED Siggia, PS Swain: Stochastic Gene Expression in a Single Cell , Science, 297, 2002, pp. 1183-1186.
  • with C. Guet, W. Hsing, S. Leibler: Combinatorial synthesis of genetic networks , Science, 296, 2002, pp. 1466-1470.
  • with S. Leibler: A synthetic oscillatory network of transcriptional regulators , Nature, 403, 2000, pp. 335-338.
  • with N. Rosenfeld, U. Alon: Negative autoregulation speeds the response times of transcription networks , J. Mol. Biol., 323, 2002, pp. 785-793
  • with MG Surette, PE Wolf, J. Stock, S. Leibler: Photoactivation turns green fluorescent protein red , Curr. Biol., 7.1997, pp. 809-812

Web links

Individual evidence

  1. ↑ Michael B. Elowitz, Arnold J. Levine, Eric D. Siggia, Peter S. Swain: Stochastic Gene Expression in a Single Cell . In: Science . tape 297 , no. 5584 , August 2002, p. 1183-1186 , doi : 10.1126 / science.1070919 , PMID 12183631 .
  2. ↑ MacArthur Foundation, Elowitz
  3. ↑ portrait of Elowitz at BWF
personal data
SURNAME Elowitz, Michael
ALTERNATIVE NAMES Elowitz, Michael B.
BRIEF DESCRIPTION American physicist and systems biologist
DATE OF BIRTH May 9, 1970