Stanislas Leibler

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Stanislas Leibler (* 1957 ) is a Polish physicist and systems biologist . He is a professor at Cornell University and the Institute for Advanced Study . Leibler is considered one of the pioneers of synthetic biology .

Life

Leibler was born in Poland in 1957. He studied physics in Warsaw and at the University of Paris , where he received his diploma in theoretical physics in 1979, received his doctorate in 1981 ( Thèse de 3 ème cycle ) and completed his habilitation in 1984 ( Thèse d'Etat ). He spent a year at the École normal supérieure and then from 1984 to 1992 at the research center in Saclay . From 1985 to 1987 he was a visiting scientist at Cornell University and from 1989 to 1991 at the École Supérieure de Physique et Chimie Industrielles . In 1992 he became Professor of Physics at Princeton University , from 1993 in the Department of Molecular Biology. In 2000/2001, in addition to his professorship in Princeton, he was also at the Howard Hughes Medical Institute and from 2001 he was a professor at Rockefeller University ( Gladys T. Perkins Professor and Head of Laboratory). From 2003 he was also ( Tri-Institute Professor ) at the Sloan-Kettering Institute for Cancer Research and Weil Medical Center at Cornell University. He has also been at the Institute for Advanced Study since 2009.

He deals both theoretically and experimentally with systems biology, i.e. the interaction of genetic and biochemical networks at the cellular level in living beings and that of populations, for example of microbes (or associations of neurons, evolution of protein families) and the complex, collective behavior resulting from this. Among other things, he and his group realized simple genetic networks in bacteria that function like clocks or logic circuits. He also considers inverse problems (inferences about the interaction of certain components from statistical correlations).

An experiment with Michael Elowitz from 2000 is considered a key experiment in synthetic biology. They built a negative feedback system of gene regulation into an artificial oscillator in E. coli ( repressilator ), recognizable by the production of dye.

In 1997/98 he was awarded a Humboldt Research Prize at the European Molecular Biology Laboratory (EMBO) in Heidelberg. In 2009 he became a Fellow of the American Physical Society (APS). For 2015 he was awarded the Max Delbruck Prize of the APS, in 2016 he was elected to the National Academy of Sciences .

Fonts

  • with M. Elowitz, C. Guet, W. Hsing: Combinatorial synthesis of genetic networks . In: Science , 296, 2002, pp. 1466-1470.
  • with Leland Hartwell, John Hopfield , Andrew Murray: From molecular to modular cell biology . In: Nature , 407, 1999, C 47-52, PMID 10591225
  • with N. Barkai: Robustness in simple biochemical networks . In: Nature , 387, 1997, pp. 913-917
  • with J. Vilar, HY Kueh, N. Barkai: Mechanisms of noise resistance in gene oscillators . In: Proc. Nat. Acad. USA , 99, 2002, pp. 5988-5992

Web links

Individual evidence

  1. ↑ M. Elowitz, S. Leibler: A synthetic oscillatory network of transcriptional regulators . In: Nature , 403, 2000, pp. 335-338
personal data
SURNAME Leibler, Stanislas
BRIEF DESCRIPTION Polish physicist and systems biologist
DATE OF BIRTH 1957