N 6 -threonylcarbamoyladenosine
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Surname | N 6 -threonylcarbamoyladenosine | ||||||||||||
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Molecular formula | C 15 H 20 N 6 O 8 | ||||||||||||
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properties | |||||||||||||
Molar mass | 412.36 g mol −1 | ||||||||||||
Physical state |
firmly |
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As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
N 6 -Threonylcarbamoyladenosin (t 6 A) is a rare nucleoside and occurs in the tRNA . It consists of β- D- ribofuranose (sugar) and a substituted adenine . It differs from adenosine by adding a threonine linkedvia a carbamate . Like N 6 -isopentenyladenosine , it is found next to the anticodon at position 37 in the tRNA. These are those tRNAs thatreadthe codon ANN (where N represents the four nucleotides A, C, G and T), i.e. tRNA Ile , tRNA Thr , tRNA Asn , tRNA Lys , tRNA Ser and tRNA Arg .
literature
- GB Chheda: "Isolation and characterization of a novel nucleoside, N - [(9-beta-D-ribofuranosyl-9H-purin-6-yl) carbamoyl] threonine, from human urine", Life Sci. , 1969 , 8 (18), pp. 979-987 ( PMID 5346949 ).
- Charles T. Lauhon: "Mechanism of N6-Threonylcarbamoyladenosine (t 6 A) Biosynthesis: Isolation and Characterization of the Intermediate Threonylcarbamoyl-AMP", Biochemistry , 2012 , 51 (44), pp. 8950-8963 ( doi : 10.1021 / bi301233d ) .
Individual evidence
- ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
- ↑ Patrick A. Limbach, Pamela F. Crain, James A. McCloskey: "Summary: the modified nucleosides of RNA", Nucleic Acids Research , 1994 , 22 (12), pp. 2183-2196 ( doi : 10.1093 / nar / 22.12 .2183 , PMC 523672 (free full text), PMID 7518580 ).
- ↑ Christopher Deutsch, Basma El Yacoubi, Valérie de Crécy-Lagard, Dirk Iwata-Reuyl: "Biosynthesis of Threonylcarbamoyl Adenosine (t 6 A), a Universal tRNA Nucleoside", J Biol Chem , 2012 , 287 (17), p. 13666 -13673 ( doi : 10.1074 / jbc.M112.344028 , PMC 3340167 (free full text), PMID 22378793 ).
- ↑ Ludovic Perrochia, Estelle Crozat, Arnaud Hecker, Wenhua Zhang, Joseph Bareille, Bruno Collinet, Herman van Tilbeurgh, Patrick Forterre, Tamara Basta: "In vitro biosynthesis of a universal t 6 A tRNA modification in Archaea and Eukarya", Nucleic Acids Res , 2013 , 41 (3), pp. 1953-1964 ( doi : 10.1093 / nar / gks1287 , PMC 3561968 (free full text), PMID 23258706 ).
- ↑ Sarah E. Kolitz, Jon R. Lorsch: "Eukaryotic Initiator tRNA: Finely Tuned and Ready for Action", FEBS Letters , 2010 , 584 (2), pp. 396-404 ( doi : 10.1016 / j.febslet. 2009.11 . 047 , PMC 2795131 (free full text), PMID 19925799 ).
Web links
- Entry for N 6 -Threonylcarbamoyladenosine in the Human Metabolome Database (HMDB) , accessed October 12, 2013.
- Modification Summary of N 6 -Threonylcarbamoyladenosine in the Modomics database, accessed on January 13, 2014.