Nabitan

Structural formula
	Mixture of four stereoisomers (structural formula without stereochemistry)
General
Non-proprietary name	Nabitan
other names	(±) -8- (1,2-Dimethylheptyl) -1,3,4,5-tetrahydro-5,5-dimethyl-2- (2-propynyl) -2 H - (1) benzopyrano [4,3- c ] pyridin-10-yl-1-piperidine butyrate; Benzopyranoperidine;
Molecular formula	C 35 H 52 N 2 O 3
External identifiers / databases
PubChem	39503
ChemSpider	36117
Wikidata	Q1962034
Drug information
Drug class	Antemetic, analgesic
Mechanism of action	Activation of the cannabinoid receptors CB1 and CB2
properties
Molar mass	548.80 g · mol -1
safety instructions
GHS hazard labeling ; no classification available
GHS hazard labeling ; no classification available
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Nabitan is a synthetic analogue of tetrahydrocannabinol (dronabinol) and is therefore one of the cannabinoids .

Effects

Nabitan has antiemetic and analgesic effects by activating the cannabinoid receptors CB1 and CB2. In animal experiments, it reduces the intraocular pressure and thus provides a drug for glaucoma is. Developed was the connection as a painkiller and as a sedative , but not for clinical applications. The very high solubility in water for a cannabinoid is advantageous.

To date, nabitan has no significance as a medicinal substance , since dronabinol or nabilone are more effective. It is only of importance as one of many test substances in the search for active substances for cannabinoids.

Individual evidence

↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
^ Raj K. Razdan: The Total Synthesis of Cannabinoids. In: The Total Synthesis of Natural Products. vol. 4, ed. John ApSimon, Wiley, Apr. 1981, pp. 239-243.
↑ Raj K. Razdan, JF Howes: Drugs related to tetrahydrocannabinol. In: Medicinal Research Reviews . 1983; 3 (2), pp. 119-146, PMID 6134882 .
^ Robert A. Archer: The cannabinoids: therapeutic potentials. In: Annual Reports in Medicinal Chemistry . 1974; 9, pp. 253-259, PMID 12307093 .

[NV-1] This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.

[2] Raj K. Razdan: The Total Synthesis of Cannabinoids. In: The Total Synthesis of Natural Products. vol. 4, ed. John ApSimon, Wiley, Apr. 1981, pp. 239-243.

[3] Raj K. Razdan, JF Howes: Drugs related to tetrahydrocannabinol. In: Medicinal Research Reviews . 1983; 3 (2), pp. 119-146, PMID 6134882 .

[4] Robert A. Archer: The cannabinoids: therapeutic potentials. In: Annual Reports in Medicinal Chemistry . 1974; 9, pp. 253-259, PMID 12307093 .