Nedocromil

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Structural formula
Structural formula of nedocromil
General
Non-proprietary name Nedocromil
other names

9-Ethyl-6,9-dihydro-4,6-dioxo-10-propyl-4 H -pyrano [3.2- g ] quinoline-2,8-dicarboxylic acid ( IUPAC )

Molecular formula
  • C 19 H 17 NO 7 (nedocromil)
  • C 19 H 15 NNa 2 O 7 (Nedocromil disodium salt )
External identifiers / databases
CAS number
  • 69049-73-6 (nedocromil)
  • 69049-74-7 (nedocromil disodium salt)
EC number 806-161-0
ECHA InfoCard 100.233.208
PubChem 50294
ChemSpider 45608
DrugBank DB00716
Wikidata Q416706
Drug information
ATC code

R01 AC07 , R03 BC03 , S01 GX04

Drug class

Antiasthmatic

properties
Molar mass
  • 371.34 g mol −1 (nedocromil)
  • 415.30 g mol −1 (nedocromil disodium salt)
Physical state

firmly

Melting point

298–300 ° C (decomposition)

solubility

soluble in water (nedocromil disodium salt)

safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances
07 - Warning

Caution

H and P phrases H: 319
P: ?
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Nedocromil is a drug that is used for the prophylaxis and treatment of allergic complaints and is sold in German-speaking countries by the company Sanofi-Aventis .

pharmacology

Area of ​​application and mode of action

In addition to cromoglicic acid, Nedocromil is used to treat seasonal allergic conjunctivitis (allergic conjunctivitis) . They both belong to the active ingredient group of cromones .

Both substances can also be administered by inhalation as an alternative to glucocorticoids in mild allergic and non-allergic asthma and prophylactically . However, Nedocromil is not suitable for the treatment of acute asthma symptoms.

Nedocromil has a stabilizing effect on the histamine- storing or -producing mast cells by inhibiting degranulation, i.e. by inhibiting the release of mediators . However, this full effect does not appear until about one month after the start of treatment.

Trade names

The monopreparations contain the disodium salt (CAS No. 69049-74-7): Irtan (D), Tilade (A) and Tilavist (A, CH).

Individual evidence

  1. ^ A b c The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals , 14th Edition (Merck & Co., Inc.), Whitehouse Station, NJ, USA, 2006; Pp. 1112-1113, ISBN 978-0-911910-00-1 .
  2. ↑ Template: CL Inventory / not harmonized There is not yet a harmonized classification for this substance . A label of [No public or meaningful name is available] in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), accessed on July 8, 2020, is reproduced from a self-classification by the distributor .
  3. ↑ ABDA database (as of July 29, 2008).
  4. ↑ Lung Information Service: Cromone ( Memento of December 22, 2015 in the Internet Archive ), accessed on December 15, 2015.