Neurin

Structural formula
General
Surname	Neurin
other names	Trimethyl vinyl ammonium hydroxide; N , N , N -trimethylethenamine hydroxide; Vinyl trimethyl ammonium hydroxide; Vitaloid;
Molecular formula	C 5 H 13 NO
Brief description	highly viscous liquid with a fish-like odor
External identifiers / databases
EC number	207-344-2
ECHA InfoCard	100.006.678
PubChem	10042
Wikidata	Q408180
properties
Molar mass	103.16 g mol −1
Physical state	liquid
Melting point	<25 ° C
solubility	soluble in water and ethanol
safety instructions
GHS hazard labeling ; no classification available
GHS hazard labeling ; no classification available
Toxicological data	30 mg · kg -1 ( LD Lo , guinea pigs , ip ) ; 100 mg kg −1 ( LD Lo , mouse , ip ) ; 46 mg kg −1 ( LD Lo , mouse , sc ) ; 90 mg kg −1 ( LD Lo , rabbit , oral ) ;
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Neurin , also known as vinyl trimethylammonium hydroxide or trimethylvinylammonium hydroxide , is a poisonous alkaloid . It is formed as part of the corpse poison in putrefaction of protein , for example, in rotting muscle meat, the elimination of water from the choline . Neurin and choline are both quaternary ammonium compounds . A differentiation from neurin is the non-toxic neuridin (or spermine ).

Emergence

In putrefaction processes, the choline contained in almost all living things is transformed into neurin when heated and dehydrated (the anion was omitted in each case):

{\ displaystyle \ mathrm {(H_ {3} C) _ {3} N ^ {+} (CH_ {2}) _ {2} OH \ {\ xrightarrow {\ Delta T}} \ \ (H_ {3} C) _ {3} N ^ {+} CH = CH_ {2} + H_ {2} O}}

toxicology

In older studies from 1926 and 1935 on guinea pigs, mice and rabbits, neurin was highly toxic; the LD _Lo values determined were between 30 and 100 mg / kg body weight of the animals used.

Individual evidence

↑ ^a ^b entry on Neurin. In: Römpp Online . Georg Thieme Verlag, accessed on September 30, 2014.
^ Entry on Neurin in the ChemIDplus database of the United States National Library of Medicine (NLM), accessed on November 27, 2018.
↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
↑ ^a ^b ^c ^d Abdernalden's Handbook of Biological Working Methods. Vol. 4, pp. 1289, 1935 .
^ ^A ^b Journal of Pharmacology and Experimental Therapeutics . Vol. 28, p. 367, 1926 .

[roempp-1] try on Neurin. In: Römpp Online . Georg Thieme Verlag, accessed on September 30, 2014.

[2] Entry on Neurin in the ChemIDplus database of the United States National Library of Medicine (NLM), accessed on November 27, 2018.

[NV-3] This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.

[ahba-4] Abdernalden's Handbook of Biological Working Methods. Vol. 4, pp. 1289, 1935 .

[jpet-5] A ^b Journal of Pharmacology and Experimental Therapeutics . Vol. 28, p. 367, 1926 .