Organo-anion transporter
| Solute carrier organic anion transporter | ||
|---|---|---|
| Mass / length primary structure | 640-722 amino acids | |
| Secondary to quaternary structure | multipass membrane protein | |
| Identifier | ||
| Gene name (s) | SLCO1A2 , SLCO1B1 , SLCO1B3 , SLCO1C1 , SLCO2A1 , SLCO2B1 , SLCO3A1 , SLCO4A1 , SLCO4C1 , SLCO5A1 , SLCO6A1 | |
| Transporter classification | ||
| TCDB | 2.A.60 | |
| designation | Organo-anion transporter | |
| Occurrence | ||
| Parent taxon | Jaws | |
Organic anion-transporting polypeptide (abbr. OATP of Engl. : O rganic A nion T ransporting P olypeptide ) are proteins in the plasma membrane of cells including the liver , kidney and blood-brain barrier , the exogenous substances from the blood into the Smuggle in cell. These membrane transporters are closely related in evolutionary terms and are mainly found in terrestrial vertebrates and fish , three of which are also found in insects . Their function is to remove bile salts , steroid hormones , drugs and other foreign substances from the blood.
Eleven of these vans are known to have been used by humans. The names of the genes coding for them begin with SLCO and the protein names usually with OATP (UniProt) or Oat (TCDB). Grouped according to their location in the body, they are
- Liver: LST-1 ( SLCO1B1 ), LST-2 ( SLCO1B3 )
- Kidney: OATP-H ( SLCO4C1 )
- Brain: OATP-A ( SLCO1A2 ), OATP-F (and in Leydig cells , SLCO1C1 )
- Testicle: OATP-I ( SLCO6A1 )
- everywhere: PGT ( SLCO2A1 ), OATP-B ( SLCO2B1 ), OATP-D ( SLCO3A1 ), OATP-E ( SLCO4A1 )
- unknown: OATP-J ( SLCO5A1 )
Individual evidence
- ↑ Hagenbuch, B. and PJ Meier: Organic anion transporting polypeptides of the OATP / SLC21 family: phylogenetic classification as OATP / SLCO superfamily, new nomenclature and molecular / functional properties. In: plowman Arch 447/5/ 2004 : 653-65. PMID 14579113
- ↑ T. Mikkaichi: The Organic Anion Transporter (OATP) Family. In: Drug Metabolism and Pharmacokinetics , 19/3/ 2004 : 171-179. doi : 10.2133 / dmpk.19.171