PRO-LAD

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Structural formula
Structural formula of PRO-LAD
General
Surname PRO-LAD
other names
  • (8β) - N , N -diethyl-6-propyl-9,10-didehydroergoline-8-carboxamide ( IUPAC )
  • N- propyl-nor-LSD
  • 9,10-didehydro-6-propyl- N , N -diethylergolin-8 β -carboxamide
  • 6-propyl- N , N- diethyl-6-norlysergamide
Molecular formula C 22 H 29 N 3 O
Brief description

colorless solid

External identifiers / databases
CAS number 65527-63-1
PubChem 44457803
Wikidata Q7120374
Drug information
Mechanism of action

Agonist at the serotonin (5-HT 2 ) receptors

properties
Molar mass 351.49 g mol −1
Physical state

firmly

Melting point

87-88 ° C

safety instructions
GHS hazard labeling
no classification available
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

PRO-LAD (engl. N - Pro pyl - normal l ysergic a cid d iethylamide ) is a chemically prepared derivative of lysergic acid , which in ergot alkaloids naturally occurs. Even in very small doses , it produces long-lasting hallucinogenic effects. Pharmacologically, PRO-LAD belongs to the group of serotonin-related psychedelic substances.

chemistry

Chemically, PRO-LAD belongs to the Ergoline structural class . The tetracyclic ergoline is characteristic of the chemical structure of ergot alkaloids . The ergolines found in nature are methylated on the nitrogen in position 6 of the ergoline system . In contrast to LSD, PRO-LAD has an N 6 - propyl group instead of an N 6 - methyl group .

  • Basic body of the Ergoline

  • LSD structural formula

  • PRO-LAD structural formula

Effect on humans

The duration of an uncomplicated PRO-LAD experience is usually between 6 and 8 hours, depending on the dosage, body weight and age. The effective dose is given as 100–200 µg . PRO-LAD acts on the receptor subtypes of the serotonin (5-HT 2 ) receptors and the dopamine receptors .

literature

  • Alexander Shulgin , Ann Shulgin: TiHKAL, the Continuation . Transform Press, Berkeley 1997, ISBN 0-9630096-9-9 ( online ).
  • Andrew J. Hoffman, David E. Nichols: Synthesis and LSD-like discriminative stimulus properties in a series of N (6) -alkyl norlysergic acid N, N-diethylamide derivatives . In: Journal of Medicinal Chemistry . tape 28 , no. September 9 , 1985, ISSN  0022-2623 , pp. 1252-1255 , doi : 10.1021 / jm00147a022 .
  • T. Niwaguchi, Y. Nakahara, H. Ishii: Studies on lysergic acid diethylamide and related compounds. IV. Syntheses of various amide derivatives of norlysergic acid and related compounds. In: Yakugaku Zasshi. Volume 96, Number 5, May 1976, pp. 673-678, ISSN  0031-6903 . PMID 987200 .
  • Robert C. Pfaff, Xuemei Huang, Danuta Marona-Lewicka, Robert Oberlender and David E. Nichols: Lysergamides Revisited. In: NIDA Research Monograph 146: Hallucinogens: An Update. P. 52, 1994, United States Department of Health and Human Services.

See also

Web links

Individual evidence

  1. ↑ a b c Alexander and Ann Shulgin: PRO-LAD . In: TiHKAL. Transform Press, Berkeley 1997, ISBN 0-9630096-9-9
  2. ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
  3. ^ Robert C. Pfaff, Xuemei Huang, Danuta Marona-Lewicka, Robert Oberlender and David E. Nichols: Lysergamides Revisited. ( Memento of the original from July 23, 2015 in the Internet Archive ) Info: The @1@ 2Template: Webachiv / IABot / archives.drugabuse.gov archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. In: NIDA Research Monograph 146: Hallucinogens: An Update. P. 52, 1994, United States Department of Health and Human Services.