ETH-LAD
Structural formula | ||||||||||
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Surname | ETH-LAD | |||||||||
other names |
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Molecular formula | C 21 H 27 N 3 O | |||||||||
Brief description |
colorless solid |
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Drug information | ||||||||||
Mechanism of action | ||||||||||
properties | ||||||||||
Molar mass | 337.46 g mol −1 | |||||||||
Physical state |
firmly |
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Melting point |
108-110 ° C |
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safety instructions | ||||||||||
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As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . |
ETH-LAD ( N - Eth yl - nor- l ysergic a cid d iethylamide ) is a chemically produced derivative of lysergic acid , which occurs naturally as an ergot alkaloid . Even in very small doses , it produces long-lasting hallucinogenic effects. Pharmacologically, ETH-LAD belongs to the group of serotonin-related psychedelic substances.
chemistry
Chemically, ETH-LAD belongs to the Ergoline structural class . The tetracyclic ergoline is characteristic of the chemical structure of ergot alkaloids . The ergolines found in nature are methylated on the nitrogen in position 6 of the ergoline system . In contrast to LSD, ETH-LAD has an N 6 - ethyl group instead of an N 6 - methyl group .
Effect on humans
The duration of an uncomplicated ETH-LAD experience is usually between 8 and 12 hours, depending on the dosage, body weight and age. The effective dose is given as 40–150 µg . ETH-LAD acts on the receptor subtypes of the serotonin (5-HT 2 ) receptors and the dopamine receptors .
literature
- Simon D. Brandt, Pierce V. Kavanagh et al. a .: Return of the lysergamides. Part III: Analytical characterization of N 6 -ethyl-6-norlysergic acid diethylamide (ETH-LAD) and 1-propionyl ETH-LAD (1P-ETH-LAD). In: Drug Testing and Analysis. 2017, doi: 10.1002 / dta.2196 .
- Alexander Shulgin , Ann Shulgin: TiHKAL, the Continuation . Transform Press, Berkeley 1997, ISBN 0-9630096-9-9 . ( online )
- VJ Watts, RB Mailman, CP Lawler, KA Neve, DE Nichols: LSD and structural analogs: pharmacological evaluation at D1 dopamine receptors . In: Psychopharmacology . tape 118 , no. 4 , April 1995, ISSN 0033-3158 , pp. 401-409 , doi : 10.1007 / BF02245940 .
- Robert C. Pfaff, Xuemei Huang, Danuta Marona-Lewicka, Robert Oberlender and David E. Nichols: Lysergamides Revisited. In: NIDA Research Monograph 146: Hallucinogens: An Update. P. 52, 1994, United States Department of Health and Human Services.
- Andrew J. Hoffman, David E. Nichols: Synthesis and LSD-like discriminative stimulus properties in a series of N (6) -alkyl norlysergic acid N, N-diethylamide derivatives . In: Journal of Medicinal Chemistry . tape 28 , no. September 9 , 1985, ISSN 0022-2623 , pp. 1252-1255 , doi : 10.1021 / jm00147a022 .
- T. Niwaguchi, Y. Nakahara, H. Ishii: Studies on lysergic acid diethylamide and related compounds. IV. Syntheses of various amide derivatives of norlysergic acid and related compounds. In: Yakugaku Zasshi. Volume 96, Number 5, May 1976, pp. 673-678, ISSN 0031-6903 . PMID 987200 .
See also
- 1P-ETH-LAD
- METH-LAD (LSD)
- AL-LAD
- PRO-LAD
Web links
Individual evidence
- ↑ a b c Alexander and Ann Shulgin: ETH-LAD . In: TiHKAL. Transform Press, Berkeley 1997, ISBN 0-9630096-9-9
- ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
- ^ VJ Watts, RB Mailman, CP Lawler, KA Neve, DE Nichols: LSD and structural analogs: pharmacological evaluation at D1 dopamine receptors. In: Psychopharmacology. 118, 1995, pp. 401-409, doi: 10.1007 / BF02245940 .