Panthenyl ethyl ether

Structural formula
General
Surname	Panthenyl ethyl ether
other names	(+) - N - (3-ethoxypropyl) -2,4-dihydroxy-3,3-dimethylbutyramide; ( R ) - N - (3-ethoxypropyl) -2,4-dihydroxy-3,3-dimethylbutyramide; D - N - (3-ethoxypropyl) -2,4-dihydroxy-3,3-dimethylbutyramide; PANTHENYL ETHYL ETHER ( INCI ) ;
Molecular formula	C 11 H 23 NO 4
External identifiers / databases
EC number	211-569-1
ECHA InfoCard	100.010.519
PubChem	94184
Wikidata	Q27277638
properties
Molar mass	233.30 g mol −1
boiling point	130 to 132 ° C (101325 Pascal, unspecified stereochemistry)
safety instructions
GHS hazard labeling ; no classification available
GHS hazard labeling ; no classification available
Toxicological data	2.000 mg kg −1 ( LD 50 , rat , oral ) ; 2,000 mg kg −1 ( LD 50 , rat , transdermal ) ;
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Panthenyl ethyl ether , more precisely ( R ) -panthenyl ethyl ether , is used both in the cosmetics industry and in the pharmaceutical industry. This is an ether made from ( R ) -panthenol and ethanol . When panthenyl ethyl ether is mentioned in this article or in the scientific literature without a stereochemical prefix, it usually means ( R ) -panthenyl ethyl ether.

use

Ingredients of shampoo

In 2016, the VCRP (Voluntary Cosmetic Registration Program) data from the FDA (Food and Drug Administration in the USA) listed 362 products that contained the active ingredient panthenyl ethyl ether. The maximum concentration used for leave-on products (active ingredients that remain on the skin, e.g. body lotions) was 2% in foundation.

Panthenyl ethyl ether can be used to treat secondarily infected, contaminated or elderly wounds, as well as to prevent the formation of excess scar tissue in humans and animals. It has the same properties as provitamin B5 (panthenol), in addition it is able to form a lipophilic suspension in which proteolytic enzymes can be integrated. Examples of possible enzymes are trypsin or chymotrypsin .

Biological effect

Panthenyl ethyl ether is absorbed through the skin and converted into pantothenic acid. ( R ) -Pantothenic acid (vitamin B5) is converted into coenzyme A in the blood . If the concentration of pantothenic acid in the blood nevertheless increases, the metabolism is stimulated and the acid is excreted through the kidneys.

Individual evidence

↑ Entry on PANTHENYL ETHYL ETHER in the CosIng database of the EU Commission, accessed on December 29, 2019.
↑ G. Erlemann, W. Guex, O. Schnider, M. Walter, F. Weber: New derivatives of panthenol. In: Perfume and Cosmetics. Volume 43, No. 2, 1962, pp. 38-40.
↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
^ ^A ^b W. F. Bergfeld, DV Belsito and Co .: Safety Assessment of Panthenol, Pantothenic Acid, and Derivatives as Used in Cosmetics. Cosmetic Ingredient Review, Washington DC, 2017, accessed September 13, 2017, PDF pp. 9, 14.
^ WF Bergfeld, DV Belsito and Co .: Safety Assessment of Panthenol, Pantothenic Acid, and Derivatives as Used in Cosmetics. Cosmetic Ingredient Review, Washington DC, 2017, accessed September 13, 2017, PDF p. 13.
↑ Patent DE10100015 : Stable, sprayable enzyme-containing composition for wound treatment and skin regeneration, comprises proteolytic enzyme (s) and panthenyl ethyl ether as a lipophilic granulation promoter. Published on August 14, 2002 , inventors: Petra Tosch, Christoph Vieten. ‌
↑ Patent US2010249043 : Compositions and methods for promoting hair growth. Published on September 30, 2010 , inventor: Lin Suan. ‌
↑ K. Lang, OF Ranke: Metabolism and nutrition. Springer Verlag, Berlin 1950, ISBN 978-3-642-92545-0 , p. 228f.
^ HW Altmann, F. Büchner, E. Letterer: Handbook of the first pathology: first part nutrition. Springer Verlag, Berlin 1962, ISBN 978-3-662-28643-2 , p. 683.

[CosIng-1] Entry on PANTHENYL ETHYL ETHER in the CosIng database of the EU Commission, accessed on December 29, 2019.

[Erlemann-2] G. Erlemann, W. Guex, O. Schnider, M. Walter, F. Weber: New derivatives of panthenol. In: Perfume and Cosmetics. Volume 43, No. 2, 1962, pp. 38-40.

[NV-3] This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.

[Bergfeld_tox_1-4] A ^b W. F. Bergfeld, DV Belsito and Co .: Safety Assessment of Panthenol, Pantothenic Acid, and Derivatives as Used in Cosmetics. Cosmetic Ingredient Review, Washington DC, 2017, accessed September 13, 2017, PDF pp. 9, 14.

[Bergfeld-5] WF Bergfeld, DV Belsito and Co .: Safety Assessment of Panthenol, Pantothenic Acid, and Derivatives as Used in Cosmetics. Cosmetic Ingredient Review, Washington DC, 2017, accessed September 13, 2017, PDF p. 13.

[DE_Patent-6] Patent DE10100015 : Stable, sprayable enzyme-containing composition for wound treatment and skin regeneration, comprises proteolytic enzyme (s) and panthenyl ethyl ether as a lipophilic granulation promoter. Published on August 14, 2002 , inventors: Petra Tosch, Christoph Vieten. ‌

[US_Patent_Haarwuchsmittel-7] Patent US2010249043 : Compositions and methods for promoting hair growth. Published on September 30, 2010 , inventor: Lin Suan. ‌

[Lang-8] K. Lang, OF Ranke: Metabolism and nutrition. Springer Verlag, Berlin 1950, ISBN 978-3-642-92545-0 , p. 228f.

[Altmann-9] HW Altmann, F. Büchner, E. Letterer: Handbook of the first pathology: first part nutrition. Springer Verlag, Berlin 1962, ISBN 978-3-662-28643-2 , p. 683.